Add-on Levetiracetam in Children With Refractory Epilepsy: A Systematic Review

Abbaskhanian, Ali; Shahmohammadi, Soheila

doi:10.17795/jpr-6276.

Volume 4, Issue 2 (7-2016) J. Pediatr. Rev 2016, 4(2): 12-18 | Back to browse issues page

‎ 10.17795/jpr-6276.

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Abbaskhanian A, Shahmohammadi S. Add-on Levetiracetam in Children With Refractory Epilepsy: A Systematic Review . J. Pediatr. Rev 2016; 4 (2) :12-18
URL: http://jpr.mazums.ac.ir/article-1-124-en.html

Add-on Levetiracetam in Children With Refractory Epilepsy: A Systematic Review

Ali Abbaskhanian

¹, Soheila Shahmohammadi²

1- Department of Pediatric Neurology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, IR Iran , snali45@yahoo.com
2- CRNA, Research Fellow, Infectious Disease Research Center with Focus on Nosocomial Infection, Bouali Sina Hospital, Mazandaran University of Medical Sciences, Sari, IR Iran

Abstract: (4151 Views)

Results: Of the nine eligible articles, 1036 patients aged ≤ 18 years were identified. Male patients (52%) were more prominent than female ones. Five articles reported that levetiracetam therapy appeared more effective against localization-related than generalized epilepsy. The dosage of levetiracetam ranged from 6 to 70 mg/kg/day, with a mean of 43.2 mg/kg/day based on the mean doses reported by four of nine reviewed articles. The mean duration of follow-up was 39 weeks (ranging from 8 - 144 weeks). Administration of levetiracetam was effective in 42.24% of the patients (responders with >50% decrease in seizure frequency), of whom 11.8% had become seizure free. The mean number of anti-epileptic drugs tried before introducing levetiracetam treatment was 4.4 (ranging 1 - 20). The most frequent side effects were psychological and behavioral changes (11.1%), followed by agitation (9.2%) and sleep disturbances (6.7%).

Keywords: Levetiracetam, Epilepsy, New Antiepileptic Drug, Childhood Refractory Epilepsy

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Type of Study: Systematic Review |
Received: 2016/04/9 | Accepted: 2016/06/1 | Published: 2016/06/26

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