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1- Department of Pediatric Endocrinology and Metabolism, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran 2- Department of Community Medicine, University of Medical Sciences, Mashhad, IR Iran 3- Medical Genetic Research Center, Department of Human Genetics, Imam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran; Department of Community Medicine, University of Medical Sciences, Mashhad, IR Iran , hosseiny.samane@gmail.com