A Systematic Review of Single Nucleotide Polymorphisms Associated With Metabolic Syndrome in Children and Adolescents

Kelishadi, Roya; Hovsepian, Silva; Haghjooy Javanmard, Shaghayegh

doi:10.5812/jpr.10536.

Volume 6, Issue 1 (1-2018) J. Pediatr. Rev 2018, 6(1): 8-19 | Back to browse issues page

‎ 10.5812/jpr.10536.

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Kelishadi R, Hovsepian S, Haghjooy Javanmard S. A Systematic Review of Single Nucleotide Polymorphisms Associated With Metabolic Syndrome in Children and Adolescents. J. Pediatr. Rev 2018; 6 (1) :8-19
URL: http://jpr.mazums.ac.ir/article-1-150-en.html

A Systematic Review of Single Nucleotide Polymorphisms Associated With Metabolic Syndrome in Children and Adolescents

Roya Kelishadi¹

, Silva Hovsepian ^*

², Shaghayegh Haghjooy Javanmard³

1- Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non Communicable Disease, Isfahan University of Medical Sciences, Isfahan, IR Iran
2- Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non Communicable Disease, Isfahan University of Medical Sciences, Isfahan, IR Iran , silvahovsepsecret@gmail.com
3- Department of Physiology, Applied Physiology research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract: (5349 Views)

Results: In this review, during primary literature search, 219 and 1025 articles were identified through PubMed and HuGE navigator database, respectively. During 2 refining steps and after quality assessment, 38 qualified articles were evaluated at the final step. According to the whole data of systematic review results, the number of total population and points of data were 14 536. Number of studied genes and related SNP were 60 and 125, respectively. SNPs of the following genes were associated with MetS: GCK, HNFAα, SHBG, PON1, adiponectin, obesity related genes (FTO, MC4R, GNPDA2, BDNF, FAIM2, NPC1, SEC16B, SH2B1, PCSK1, KCTD15, and BAT2), PAI, AT1R, and SR-BI. SNPs of the following genes were associated with component of MetS: GCK, ACE, ABCA1, SREBP-1, miR-33b, PAI, IL6R, IL18, TCF7L2, ADRB2, and TNFα. SNPs of the following genes did not have any association with MetS or its components: CRP, APOA5, PPARγ, PGC-1γ, Tfam.

Keywords: Metabolic Syndrome, Child, Adolescents, Polymorphism, Genes

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Type of Study: Systematic Review |
Received: 2017/01/17 | Accepted: 2017/05/2 | Published: 2017/10/8

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