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1- Department of Pediatrics, Faculty Member of School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2- Department of Midwifery, Faculty of Medicine, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran ,
Abstract:   (442 Views)
Context: Premature rupture of membrane is an important complication during pregnancy and is responsible for one third of preterm labors, which is associated with the neonatal and delivery outcomes.
Objective: The present study aimed to investigate the risk factors of premature rupture of membrane and its delivery and neonatal implications.
Data Sources: For this study, the articles on the databases including PubMed, Cochrane Library, ISI and Google Scholar up to 2017 were searched. The keywords used were premature rupture of membrane, neonatal, risk factors, maternal and delivery.
Study Selection: The inclusion criteria were: articles on the relationship between maternal risk factors and premature rupture of membrane; neonatal outcomes of the premature rupture of membrane; the delivery outcomes of premature rupture of membrane; the study of mothers and infants; English and Persian language articles; and sufficient information on the state of the premature rupture of membrane. The articles investigating amniotomy or that only their abstract were available were excluded from the study.
Data Extraction: The data extracted from the above mentioned databases were illustrated with the following titles in the Excel software: authors' names and surnames, year; type of study; place of study; case group; control group; maternal risk factors; delivery outcomes, and neonatal outcomes of PROM, and the results of the study.
Results: Out of 90 articles, 15 articles were finalized including 1 prospective study, 5 cross-sectional papers, 6 retrospective articles and 3 historical cohort studies. Maternal risk factors included: age, parity, education, occupation, diabetes, blood pressure, cervical length along with abortion history, history of infection,  upper urinary tract infection, sexual transmitted  disease, positive vaginal culture, no antibiotic use at the time of admission, chorioamnionitis, history of PROM, addiction, placental abruption, pre-eclampsia and cerclage. Moreover, delivery complications were: cesarean section, oligohydramnios, chorioamnionitis, placental abruption, fetal distress, fever during labor, placenta Previa, infection, prenatal bleeding, maternal sepsis, and need for antibiotic therapy, placental retention and puerperal endometritis. Neonatal complications included: prematurity, respiratory distress syndrome, asphyxia, infection, meningitis, sepsis, pneumonia, perinatal mortality, patent arterial duct, necrotizing enterocolitis, IVH, pulmonary hypoplasia, hyperbilirubinemia, and antibiotic intake.
Conclusion: Based on the results of this study, the most important risk factors for PROM, were diabetes and maternal hypertension which were associated with neonatal and maternal complications. The most important maternal and neonatal complication is infection.
Full-Text [PDF 489 kb]   (264 Downloads)    
Type of Study: Systematic Review |
Received: 2018/02/20 | Accepted: 2018/05/5 | Published: 2018/06/11