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Volume 8, Issue 2 (4-2020)
J. Pediatr. Rev 2020, 8(2): 133-138 |
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Karami H, Ghaffari J, Moradi S, Vahedi L, Mohammadi-Kharkeshi F. Humoral and Complement Systems in Children With Acute Immune Thrombocytopenic Purpura. J. Pediatr. Rev 2020; 8 (2) :133-138
URL: http://jpr.mazums.ac.ir/article-1-236-en.html
URL: http://jpr.mazums.ac.ir/article-1-236-en.html
1- Pediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
2- Pediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran. , javadneg@yahoo.com
3- Community Medicine Specialist, Education Development Center, Mazandaran University of Medical Sciences, Sari, Iran.
4- Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
5- Pediatrician, Mazandaran University of Medical Sciences, Sari, Iran.
2- Pediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran. , javadneg@yahoo.com
3- Community Medicine Specialist, Education Development Center, Mazandaran University of Medical Sciences, Sari, Iran.
4- Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
5- Pediatrician, Mazandaran University of Medical Sciences, Sari, Iran.
Abstract: (4943 Views)
Background: Immune thrombocytopenia (ITP) is an autoimmune disorder associated with decreased platelet production and accelerated platelet destruction. An impaired immune system may induce by or be associated with ITP.
Objectives: This study aimed to evaluate complement and humoral immune systems in ITP.
Methods: We evaluated 30 children (under 19 years old) with acute and chronic ITP referred to a tertiary hospital and compared them with 30 healthy volunteers. We assessed the samples’ CBC with differentiation, serum immunoglobulins (IgG, IgE, IgM, IgA, IgG1, IgG2, IgG3, IgG4) by nephelometry, antistreptolysin O titer by agglutination, CH50, C3, C4 by nephelometry, CD19 by flow cytometry, and anti-tetanus antibody titer by ELISA. Their demographic data were obtained with a questionnaire.
Results: Our findings showed that humoral and complement components were normal in both patients and healthy groups. However, based on independent t test results, the mean serum levels of IgM, IgE, IgG1, C3, and tetanus antibody levels were significantly higher in the patient group.
Conclusions: Humoral and complementary immunodeficiency in these patients is unlikely. However, more studies with larger sample sizes are needed.
Objectives: This study aimed to evaluate complement and humoral immune systems in ITP.
Methods: We evaluated 30 children (under 19 years old) with acute and chronic ITP referred to a tertiary hospital and compared them with 30 healthy volunteers. We assessed the samples’ CBC with differentiation, serum immunoglobulins (IgG, IgE, IgM, IgA, IgG1, IgG2, IgG3, IgG4) by nephelometry, antistreptolysin O titer by agglutination, CH50, C3, C4 by nephelometry, CD19 by flow cytometry, and anti-tetanus antibody titer by ELISA. Their demographic data were obtained with a questionnaire.
Results: Our findings showed that humoral and complement components were normal in both patients and healthy groups. However, based on independent t test results, the mean serum levels of IgM, IgE, IgG1, C3, and tetanus antibody levels were significantly higher in the patient group.
Conclusions: Humoral and complementary immunodeficiency in these patients is unlikely. However, more studies with larger sample sizes are needed.
Type of Study: Original Article |
Subject:
Allergy and Clinical Immunology
Received: 2019/04/7 | Accepted: 2019/06/9 | Published: 2020/04/1
Received: 2019/04/7 | Accepted: 2019/06/9 | Published: 2020/04/1
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