یکشنبه 16 اردیبهشت 1403
چکیده: (295 مشاهده)
Context: Prevalence of short stature reported high in thalassemia major (TM) patients. It causes mental and social problems for them. As different cut-off point for growth retardation suggested in these patients, so it is very desirable if we find a careful cut-off age using statistical analysis to help patients before it is too late.
Evidence Acquisition: Data from 803 TM patients extracted from questionnaires filled face to face by operator. It contained demographic data, family, medical and drug history. All of height and weight measurements did only by one device. Mean age was 20 ± 7 y/o and 420 were females. Children (less than 20 y/o) formed 47% of participants. Patients that reported a major risk factor for osteoporosis omitted from this study. SPSS software used for statistical analysis
Results: Short stature found in 32% of patients. Being 10 and 11 y/o and older increased the risk of short stature, 28.5 and 21.4 times, respectively compared to younger patients (both P values <0.001). On the other hand after 7 y/o and to 18 y/o -like 10 y/o and 11 y/o- increases the risk of short stature. Also being 27 y/o and 30 y/o and older increases the risk short stature, 1.4 and 1.7 times, respectively compared to younger patients (P values, 0.042 and <0.018, respectively).
Conclusion: By our findings, we suggest that awareness about short stature and monitoring for it in thalassemics, should be done in their childhood. As we found being 7 y/o and older increases of risk of short stature, we suggest start of monitoring as early as 5 y/o.
Evidence Acquisition: Data from 803 TM patients extracted from questionnaires filled face to face by operator. It contained demographic data, family, medical and drug history. All of height and weight measurements did only by one device. Mean age was 20 ± 7 y/o and 420 were females. Children (less than 20 y/o) formed 47% of participants. Patients that reported a major risk factor for osteoporosis omitted from this study. SPSS software used for statistical analysis
Results: Short stature found in 32% of patients. Being 10 and 11 y/o and older increased the risk of short stature, 28.5 and 21.4 times, respectively compared to younger patients (both P values <0.001). On the other hand after 7 y/o and to 18 y/o -like 10 y/o and 11 y/o- increases the risk of short stature. Also being 27 y/o and 30 y/o and older increases the risk short stature, 1.4 and 1.7 times, respectively compared to younger patients (P values, 0.042 and <0.018, respectively).
Conclusion: By our findings, we suggest that awareness about short stature and monitoring for it in thalassemics, should be done in their childhood. As we found being 7 y/o and older increases of risk of short stature, we suggest start of monitoring as early as 5 y/o.
نوع مطالعه: Research Article |
دریافت: 1401/7/26 | پذیرش: 1398/4/28
دریافت: 1401/7/26 | پذیرش: 1398/4/28
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