یکشنبه 16 اردیبهشت 1403
چکیده: (306 مشاهده)
Background: Failure to Thrive (FTT) is known as one of the common developmental disorders in infants. Although the improvement effect of zinc supplementation in these patients was reported in some past studies, the results were conflicting.
Objective: This study aimed to investigate the effect of zinc supplementation on factors related to growth in infants with FTT by conducting a meta-analysis.
Methods: Medline, Web of Science, and Scopus databases were comprehensively searched to find RCTs investigating the effect of zinc on growth-related factors in infants with FTT. Eligible studies were extracted after screening their relevant information. The pooled effect size was estimated as a weighted mean difference with a 95% confidence interval using the random effect model method.
Results: Out of 85 reviewed papers, 4 studies were eligible to enter this review. The present meta-analysis revealed that zinc supplementation in infants with FTT led to a significant increase in weight (WMD, -0.25 Kg; 95% CI, (0.02 to 0.49), weight-for-age Z-score (WMD, 0.16; 95% CI, (0.03 to 0.28), and height-for-age Z-score (WMD, 0.15; 95% CI, (0.001 to 0.30), compared to control groups. In contrast, zinc supplementation had no significant effect on height and IGF-1 serum level.
Conclusion: The findings of the current meta-analysis indicated the effectiveness of zinc supplementation in improving the developmental status of infants with FTT. However, due to the small number of included trials, it was impossible to draw definitive conclusions, and conducting RCTs with a larger sample size and higher sensitivity is needed.
Objective: This study aimed to investigate the effect of zinc supplementation on factors related to growth in infants with FTT by conducting a meta-analysis.
Methods: Medline, Web of Science, and Scopus databases were comprehensively searched to find RCTs investigating the effect of zinc on growth-related factors in infants with FTT. Eligible studies were extracted after screening their relevant information. The pooled effect size was estimated as a weighted mean difference with a 95% confidence interval using the random effect model method.
Results: Out of 85 reviewed papers, 4 studies were eligible to enter this review. The present meta-analysis revealed that zinc supplementation in infants with FTT led to a significant increase in weight (WMD, -0.25 Kg; 95% CI, (0.02 to 0.49), weight-for-age Z-score (WMD, 0.16; 95% CI, (0.03 to 0.28), and height-for-age Z-score (WMD, 0.15; 95% CI, (0.001 to 0.30), compared to control groups. In contrast, zinc supplementation had no significant effect on height and IGF-1 serum level.
Conclusion: The findings of the current meta-analysis indicated the effectiveness of zinc supplementation in improving the developmental status of infants with FTT. However, due to the small number of included trials, it was impossible to draw definitive conclusions, and conducting RCTs with a larger sample size and higher sensitivity is needed.
نوع مطالعه: Meta-analysis Review |
دریافت: 1402/8/20 | پذیرش: 1398/4/28
دریافت: 1402/8/20 | پذیرش: 1398/4/28
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