Volume 2, Number 1 (2-2014)                   JPR 2014, 2(1): 62-74 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Shahmohammadi S, Saffar M J, Rezai M S. BCG-osis after BCG vaccination in immunocompromised children: Case series and review. JPR. 2014; 2 (1) :62-74
URL: http://jpr.mazums.ac.ir/article-1-67-en.html

Associated Professor
Abstract:   (13294 Views)
Bacillus Calmette Guerin (BCG) developed by Albert Calmette and Camille Guerin in France between 1908 and 1921 contained a live attenuated strain of Mycobacterium bovis and was administered worldwide to prevent tuberculosis. BCG vaccination is also administered at birth to all the newborns in Iran. Disseminated BCG infection after BCG vaccination is rare. Here in, we report 2 new cases of disseminated BCG infection and review 15 additional cases identified from our previous retrospective study during a 5-year period from 2005-2010. All of these reported patients were vaccinated. Impaired immunity was detected in 10 cases (59%) including severe combined immunodeficiency, chronic granulomatous disease, Mendelian susceptibility to mycobacterial disease, combined variable immunodeficiency, and HIV infection. Response to therapy was poor among those patients with immune deficiencies, but the overall mortality rate was 32.3%. Disseminated BCG infection is a rare but devastating complication of vaccination. Immune-compromised children are at high risk of developing BCG related complications including regional BCG-itis or disseminated disease BCG-osis.
Full-Text [PDF 970 kb]   (3704 Downloads)    
Type of Study: Systematic Review | Subject: pediatric Infectious d.
Received: 2013/12/8 | Accepted: 2014/01/7 | Published: 2014/01/7

Add your comments about this article : Your username or email:
Write the security code in the box

Send email to the article author


© 2015 All Rights Reserved | Journal of Pediatrics Review

Designed & Developed by : Yektaweb