Journal of Pediatrics Review
Journal of Pediatrics Review
J. Pediatr. Rev
Medical Sciences
http://jpr.mazums.ac.ir
1
admin
2322-4398
2322-4401
10.32598
en
jalali
1395
4
1
gregorian
2016
7
1
4
2
online
1
fulltext
en
Alterations in Humoral Immunity After Partial Versus Total Tonsillectomy: A Pilot Study and Systematic Review of Literature
Systematic Review
Systematic Review
<aside>
<p><b>Background:</b> The palatine tonsils are secondary lymphoid organs, important in sampling antigens directly from the epithelial surfaces. They produce antibodies locally and distally through their migrating B cells.</p>
</aside>
<aside>
<p><b>Objectives:</b> The aim of this study was to compare the changes in serum and saliva immunoglobulin (Ig) levels after total vs. partial tonsillectomy and also to systematically review the literature regarding the changes in humoral immunity following tonsillar surgery.</p>
</aside>
<aside>
<p><b>Patients and Methods:</b> Children with obstructive tonsils were recruited in a pilot study and randomized to undergo total or partial tonsillectomy. Blood and saliva samples were obtained immediately preoperatively and within 3 months postoperatively, to measure serum Ig (G, M and A) and saliva secretory IgA concentrations. Patients’ clinical history was reviewed at one year postoperatively. Systematic literature review regarding the effects of tonsillar surgery on humoral immunity was performed, using Medline, Embase and Cochrane.</p>
</aside>
<aside>
<p><b>Results:</b> Nineteen patients completed the study (11 partial, 8 total). No statistically significant changes noted in the serum Ig’s level in both groups, except for IgM which increased (P = 0.018) after partial tonsillectomy, mainly in males (P = 0.04), and in those aged 5 years and older (P = 0.02). There was noticeable decrease in susceptibility to infections. Four out of 30 studies (406 out of 1796 patients) showed decrease in some elements of the humoral immunity or suspected a negative impact of tonsillectomy on the immune system.</p>
</aside>
<aside>
<p><b>Conclusions:</b> Partial tonsillectomy does not seem to offer an immunological advantage over total tonsillectomy. The literature does not imply a significant negative impact of tonsillectomy on the humoral immune system.</p>
</aside>
Humoral Immunity, Partial Vs, Total Tonsillectomy, Serum and Saliva Immunoglobulin
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http://jpr.mazums.ac.ir/browse.php?a_code=A-10-30-49&slc_lang=en&sid=1
Mohamad A
Bitar
10031947532846001140
10031947532846001140
Yes
Pediatric Otolaryngology Program, Al-Jalila Children’s Specialty Hospital, Dubai, UAE
Charbel
Rameh
10031947532846001141
10031947532846001141
No
Nour F
Ataya
10031947532846001142
10031947532846001142
No
Alik
Najarian
10031947532846001143
10031947532846001143
No
Marita
Chakhtoura
10031947532846001144
10031947532846001144
No
Alexander
Abdelnoor
10031947532846001145
10031947532846001145
No