en Narrative Review Narrative Review <aside style="box-sizing: border-box; font-family: Arial; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; margin: 0px 0px 10px; text-align: justify;"><b style="box-sizing: border-box;">Context:</b>&nbsp;Atopic dermatitis is a chronic, relapsing skin disorder that affects all ages including infancy and childhood. There are many proved and unproved treatments for atopic dermatitis.</p> </aside> <aside style="box-sizing: border-box; font-family: Arial; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; margin: 0px 0px 10px; text-align: justify;"><b style="box-sizing: border-box;">Evidence Acquisition:</b>&nbsp;Data sources of this narrative review included studies about pediatric atopic dermatitis with the following keywords, pediatric, atopic dermatitis, immunity, acute, chronic, pruritic inflammatory skin disorder, infancy, childhood, diagnosis, management and treatment. All of the articles were written in English language with full text on management or treatment.</p> </aside> <aside style="box-sizing: border-box; font-family: Arial; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; margin: 0px 0px 10px; text-align: justify;"><b style="box-sizing: border-box;">Results:</b>&nbsp;Innate and adaptive immune system involved atopic dermatitis. Major characteristics of atopic dermatitis include pruritus, chronic or relapsing lesions and personal or family history of atopic disease. There is no specific treatment for atopic dermatitis. The treatment included rehydration, emollients, topical steroid, calcineurin inhibitors and immunosuppressant. Crisaborole topical ointment, a PDE4 anti-inflammatory topical agent (phase three of the research) could be effective in atopic dermatitis.</p> </aside> <aside style="box-sizing: border-box; font-family: Arial; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; margin: 0px 0px 10px; text-align: justify;"><b style="box-sizing: border-box;">Conclusions:</b>&nbsp;Avoidance from trigger factors and emollients are basic treatments of atopic dermatitis.</p> </aside> Pediatrics, Dermatitis, Atopic, Theapy 51 61 http://jpr.mazums.ac.ir/browse.php?a_code=A-10-30-61&slc_lang=en&sid=1 Masoud Golpour 10031947532846002273 10031947532846002273 No Department of Dermatology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, IR Iran Javad Ghaffari javadneg@yahoo.com 10031947532846002274 10031947532846002274 Yes Infectious Disease Research Center with Focus on Nosocomial Infection, Bou-Ali Sina Hospital, Mazandaran University of Medical Sciences, Sari, IR Iran Abbas Dabbaghzadeh 10031947532846002275 10031947532846002275 No Infectious Disease Research Center with Focus on Nosocomial Infection, Bou-Ali Sina Hospital, Mazandaran University of Medical Sciences, Sari, IR Iran Javad Rezaiefard 10031947532846002276 10031947532846002276 No Faculty of Medicine, Mazandaran University of Medical sciences, Sari, Iran