en Systematic Review Systematic Review <aside style="box-sizing: border-box; font-family: Arial; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; margin: 0px 0px 10px; text-align: justify;"><b style="box-sizing: border-box;">Context:</b>&nbsp;Metabolic syndrome (MetS) is defined as clustering of risk factors including obesity, dyslipidemia, hyperglycemia, and hypertension, which is associated with increased risk of cardiovascular disease (CVD) and Type 2 diabetes mellitus (T2DM).</p> </aside> <aside style="box-sizing: border-box; font-family: Arial; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; margin: 0px 0px 10px; text-align: justify;"><b style="box-sizing: border-box;">Objectives:</b>&nbsp;The present study aimed at reviewing all reported single-nucleotide polymorphisms (SNPs) related to childhood metabolic syndrome (MetS).</p> </aside> <aside style="box-sizing: border-box; font-family: Arial; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; margin: 0px 0px 10px; text-align: justify;"><b style="box-sizing: border-box;">Data Sources:</b>&nbsp;In this review, an electronic literature search was conducted in PubMed and Huge Navigator database. For the HuGE Navigator search, we used the &ldquo;metabolic syndrome&rdquo; search term. For the PubMed search, we used &ldquo;metabolic syndrome&rdquo;, &ldquo;child&rdquo;, &ldquo;adolescents&rdquo;, &ldquo;pediatrics&rdquo;, &ldquo;genes&rdquo;, and &ldquo;polymorphism&rdquo;, without any restriction for time and language.</p> </aside> <aside style="box-sizing: border-box; font-family: Arial; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; margin: 0px 0px 10px; text-align: justify;"><b style="box-sizing: border-box;">Study Selection:</b>&nbsp;Human studies with cross-sectional or case-control designs, which contained MetS as outcome and recruited participants younger than 21 years, were included. All definitions of pediatrics MetS were acceptable.</p> </aside> <aside style="box-sizing: border-box; font-family: Arial; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; margin: 0px 0px 10px; text-align: justify;"><b style="box-sizing: border-box;">Data Extraction:</b>&nbsp;This study was designed as systematic review without meta-analysis in accordance with the preferred reporting item for systematic reviews meta-analysis (PRISMA) statement recommendation. After excluding duplicated and irrelevant studies, data extraction and quality control were conducted by 2 researchers using STROBE checklist.</p> </aside> <aside style="box-sizing: border-box; font-family: Arial; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; margin: 0px 0px 10px; text-align: justify;"><b style="box-sizing: border-box;">Results:</b>&nbsp;In this review, during primary literature search, 219 and 1025 articles were identified through PubMed and HuGE navigator database, respectively. During 2 refining steps and after quality assessment, 38 qualified articles were evaluated at the final step. According to the whole data of systematic review results, the number of total population and points of data were 14 536. Number of studied genes and related SNP were 60 and 125, respectively. SNPs of the following genes were associated with MetS: GCK, HNFA&alpha;, SHBG, PON1, adiponectin, obesity related genes (FTO, MC4R, GNPDA2, BDNF, FAIM2, NPC1, SEC16B, SH2B1, PCSK1, KCTD15, and BAT2), PAI, AT1R, and SR-BI. SNPs of the following genes were associated with component of MetS: GCK, ACE, ABCA1, SREBP-1, miR-33b, PAI, IL6R, IL18, TCF7L2, ADRB2, and TNF&alpha;. SNPs of the following genes did not have any association with MetS or its components: CRP, APOA5, PPAR&gamma;, PGC-1&gamma;, Tfam.</p> </aside> <aside style="box-sizing: border-box; font-family: Arial; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; margin: 0px 0px 10px; text-align: justify;"><b style="box-sizing: border-box;">Conclusions:</b>&nbsp;The findings of this review revealed that most reported SNPs are related to lipid disorders mainly triglyceride and HDL and insulin resistance. It is suggested that combination effect of most of the reported SNPs or their interaction with environmental factors would be more effective for development of MetS in children.</p> </aside> Metabolic Syndrome, Child, Adolescents, Polymorphism, Genes 8 19 http://jpr.mazums.ac.ir/browse.php?a_code=A-10-30-74&slc_lang=en&sid=1 Roya Kelishadi 10031947532846002321 10031947532846002321 No Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non Communicable Disease, Isfahan University of Medical Sciences, Isfahan, IR Iran Silva Hovsepian silvahovsepsecret@gmail.com 10031947532846002322 10031947532846002322 Yes Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non Communicable Disease, Isfahan University of Medical Sciences, Isfahan, IR Iran Shaghayegh Haghjooy Javanmard 10031947532846002323 10031947532846002323 No Department of Physiology, Applied Physiology research Center, Isfahan University of Medical Sciences, Isfahan, Iran