en Narrative Review Narrative Review <aside style="box-sizing: border-box; font-family: Arial; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; margin: 0px 0px 10px; text-align: justify;"><b style="box-sizing: border-box;">Context:</b>&nbsp;The association between periodontal disease (PD) and cardiovascular disease (CVD) has been evaluated in many epidemiological studies; however, the results are controversial. Herein, we aimed to review if the childhood periodontal diseases are associated with future cardiovascular events or not.</p> </aside> <aside style="box-sizing: border-box; font-family: Arial; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; margin: 0px 0px 10px; text-align: justify;"><b style="box-sizing: border-box;">Evidence Acquisition:</b>&nbsp;The current literature regarding childhood periodontal disease and future cardiovascular events in children aged less than 18 years was searched on PubMed, Scopus, ISI, and Google Scholar from January 2005 to March 2017. All studies investigating the association between periodontal disease and CVD were searched by using the following search terms: &ldquo;coronary artery disease&rdquo;, &ldquo;coronary disease&rdquo;, &ldquo;heart disease&rdquo;, &ldquo;ischemic heart disease&rdquo;, &ldquo;myocardial infarction&rdquo;, Children, &ldquo;periodontal disease&rdquo;, and &ldquo;periodontitis&rdquo;.</p> </aside> <aside style="box-sizing: border-box; font-family: Arial; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; margin: 0px 0px 10px; text-align: justify;"><b style="box-sizing: border-box;">Results:</b>&nbsp;The most common form of periodontal disease is gingival bleeding and calculus. Periodontitis is associated with an elevated level of CRP, fibrinogen, and cytokines, which involved in the pathogenesis of atherosclerosis-induced disease.</p> </aside> <aside style="box-sizing: border-box; font-family: Arial; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; margin: 0px 0px 10px; text-align: justify;"><b style="box-sizing: border-box;">Conclusions:</b>&nbsp;Timely diagnosis and treatment of periodontal diseases is essential to maintain good oral health and help to decrease pathological changes like atherosclerosis, acute MI and stroke.</p> </aside> Atherosclerosis, Coronary Artery Disease, Periodontitis, Risk Factor 44 48 http://jpr.mazums.ac.ir/browse.php?a_code=A-10-30-78&slc_lang=en&sid=1 Shahryar Karami 10031947532846002330 10031947532846002330 No Department of Dentistry, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran Nazanin Ghobadi 10031947532846002331 10031947532846002331 No Department of Dentistry, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran Amirhossein Pakravan 10031947532846002332 10031947532846002332 No Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran Mojdeh Dabirian dr.dabirian@gmail.com 10031947532846002333 10031947532846002333 Yes Cardiologist, Clinical Research Development Unit of Bou-Ali Sina Hospital, Mazandaran university of Medical Sciences, Sari, Iran Farhad Sobouti 10031947532846002334 10031947532846002334 No Orthodontic Department, Dental Faculty, Mazandaran University of Medical Sciences, Sari, Iran