en ایمنولوژی Immunology Case & Review Case & Review <div style="text-align: justify;"><strong>Introduction: </strong>Common Variable Immunodeficiency (CVID) is one of the primary immunodeficiencies that its patients can develop its symptoms since infancy till senility; however, it usually manifests between the age of 15 and 40 years. It is characterized by low antibody levels and recurrent infections.&nbsp; Individuals with CVID are more prone to autoimmune diseases and malignancy.<br> <strong>Case presentation:</strong> We presented a 17-year-old girl with a documented CVID, who was treated with intravenous immunoglobulin and prophylactic antibiotics.&nbsp; She suffered from CVID from the age of 13 to the study time. She was hospitalized due to illness, fever, and severe dyspnea. Her chest X-ray revealed cardiomegaly; thus, high-resolution thorax CT scan and echocardiography were performed which revealed pericardial effusion. No underlying autoimmune diseases were detected in our assessments. Significant clinical, radiographic and physiological improvements were achieved after conducting an appropriate therapy. The patient was followed for two years and showed no clinical and laboratory findings in respect to autoimmune diseases. In our case, the pericardial effusion was present without any evidence of autoimmunity.<br> <strong>Conclusions:</strong> Cardiac manifestation and complications are rare in CVID patients in the absence of an autoimmune disease; however, they should be considered.</div> Autoimmunity, Common variable immunodeficiency, Pericardial effusion 177 180 http://jpr.mazums.ac.ir/browse.php?a_code=A-10-367-1&slc_lang=en&sid=1 Payam Payandeh dr.payandeh@gmail.com 10031947532846003740 10031947532846003740 No Department of Immunology and Allergy, School of Medicine, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. Maryam Khoshkhui arc@mums.ac.ir 10031947532846003741 10031947532846003741 Yes Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Farahzad Jabbari Azad jabbarif@mums.ac.ir 10031947532846003742 10031947532846003742 No Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Reza Farid Hosseini rfaridh@gmail.com 10031947532846003743 10031947532846003743 No Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.