en Neurology Original Article Original Article <div style="text-align: justify;"><strong>Background</strong>: Febrile Seizure (FS) which has different causes, is the most prevalent seizure type in children. Studies supported the role of Zinc (Zn) in FS.&nbsp;<br> <strong>Objectives</strong>: The present study aimed to evaluate the serum and Cerebrospinal Fluid (CSF) Zn level in children with FS.&nbsp;<br> <strong>Methods</strong>: This cross-sectional study was performed on 50 patients with FS aged 6 months-6 years in Amirkola Children&rsquo;s Hospital in 2013-2014. The required demographic and clinical data were recorded employing a checklist. The serum and CSF Zn levels were determined using Atomic Absorption Spectrophotometry (AAS) method. The collected data were analyzed in SPSS using the Chi-squared teste, Independent Samples t-test, and Pearson correlation coefficient.<br> <strong>Results</strong>: The mean&plusmn;SD age of the explored patients was 12.78&plusmn;8.38 months and their mean&plusmn;SD serum Zn level was equal to 0.68&plusmn;0.62 &micro;g/L. In total, 34(68%) of these 50 children presented Zn deficiency. The mean&plusmn;SD CSF Zn level was measured as 33.29&plusmn;11.84 &micro;g/L. Moreover, the mean&plusmn;SD CSF Zn level was equal to 37.71&plusmn;10.82 and 31.21&plusmn;11.87 in normal and abnormal serum Zn groups, respectively. In terms of mean CSF Zn level, there was no significant difference between the studied patients with healthy and decreased serum Zn level; (P=0.07). No significant difference was found between the demographic/clinical characteristics of the investigated patients with FS and normal/abnormal serum levels of Zn (P>0.05).&nbsp;<br> <strong>Conclusions</strong>: The obtained data revealed that a significant number of patients with FS had decreased serum Zn level; however, no association was detected between serum and CSF Zn concentration levels.</div> Febrile seizure, Seizures, Zinc, Epilepsy 201 208 http://jpr.mazums.ac.ir/browse.php?a_code=A-10-696-2&slc_lang=en&sid=1 Mohammadreza Salehi Omran 10031947532846005623 10031947532846005623 No Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. Saleh Valiollahi salehvalielahi@yahoo.com 10031947532846005624 10031947532846005624 Yes Student Research Committee, Babol University of Medical Sciences, Babol, Iran. Hadi Parsian 10031947532846005625 10031947532846005625 No Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. & Department of Clinical Biochemistry, Babol University of Medical Sciences, Babol, Iran. Abbas Mosapour 10031947532846005626 10031947532846005626 No Department of Clinical Biochemistry, Babol University of Medical Sciences, Babol, Iran. Ali Bijani 10031947532846005627 10031947532846005627 No Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. Mohammad Pournasrollah 10031947532846005628 10031947532846005628 No Clinical Research Development Unit of Amirkola Children’s Hospital, Babol University of Medical Sciences, Babol, Iran.