en Dermatology Narrative Review Narrative Review <div style="text-align: justify;"><strong>Context</strong>: Warts are benign cutaneous and mucosal growths caused by human papillomavirus. Warts are the most common skin diseases seen by pediatric dermatologists. Warts are often self-limited, especially in children, but some lesions are not resolved despite repeated treatments and referred to as recalcitrant warts.&nbsp;<br> <strong>Evidence acquisition</strong>: Electronic databases such as Google Scholar, PubMed, and Scopus were searched during 2000-2018 and a review was conducted for articles published in English on pediatric warts by focusing on recalcitrant warts.<br> <strong>Results</strong>: If warts are asymptomatic and being in a location that causes no cosmetic or other problems, observation is the ideal management course. Most parents and children prefer treatment for their warts. There are three modalities of treatment: medical, surgical, and immunotherapy.<br> <strong>Conclusions</strong>: Treatment of warts is a therapeutic challenge that depends on the patient&rsquo;s age and the type of warts. Despite treatment according to evidence-based guidelines, a significant proportion of warts are failed to respond. This condition is an unsolved problem in practice. The management for treating these lesions has remained unclear and a wide range of the second line of treatments has been developed.</div> Recalcitrant warts, Warts, Treatment, Children 237 246 http://jpr.mazums.ac.ir/browse.php?a_code=A-10-148-2&slc_lang=en&sid=1 Armaghan Kazeminejad armaghanjgh@yahoo.com 10031947532846006099 10031947532846006099 No Department of Dermatology, Faculty of Medicine, Mazandaran University of Medical Science, Sari, Iran. Mohammad Jafar Ghahari onlinejgh@yahoo.com 10031947532846006100 10031947532846006100 No Department of Health, Faculty of Health Sciences, Mazandaran University of Medical Science, Sari, Iran. Zohreh Hajheydari zhajheydari@yahoo.com 10031947532846006101 10031947532846006101 Yes Department of Dermatology, Faculty of Medicine, Mazandaran University of Medical Science, Sari, Iran.