en Pediatric Hematology and Oncology Case Report and Review of Literature Case Report and Review of Literature <strong>Introduction</strong>: Digital clubbing (hypertrophic osteoarthropathy) as the initial presentation of lymphoma is rarely reported, particularly in children. In this study, we report a patient with intrathoracic Hodgkin Disease (HD) and digital clubbing as the first presentation, and we will review the literature regarding the same condition.&nbsp;<br> <strong>Case Presentation</strong>: A 10-year-old boy presented with a 2-month history of cough, mild dyspnea, and night sweats, with prominent digital clubbing. A chest x-ray and a computed tomography scan of the chest showed multiple mediastinal masses. A mediastinal lymph node biopsy was done. Pathologic examination was indicative of nodular sclerosis HD.<br> <strong>Conclusions</strong>: In patients with digital clubbing, intrathoracic malignancies should be considered a differential diagnosis and must be ruled out by precise examination and paraclinical help.<br> <gdiv></gdiv><gdiv></gdiv> Osteoarthropathy, Digital clubbing, Hodgkin disease, Children 239 246 http://jpr.mazums.ac.ir/browse.php?a_code=A-10-786-1&slc_lang=en&sid=1 Hossein Karami karami_oncologist@yahoo.com 10031947532846007111 10031947532846007111 No Thalassemia Research Center (TRC), Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran. Amir Mohammad Beyzaee Amir_beyzaee@yahoo.com 10031947532846007112 10031947532846007112 No Student Research Committe, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Farzad Masiha dr.masiha56@gmail.com 10031947532846007113 10031947532846007113 No Pediatric Infectious Diseases Research Center, Communicable Disease Institute, Mazandaran University of Medical Sciences, Sari, Iran. Maryam Ghasemi a.zghasemi@yahoo.com 10031947532846007114 10031947532846007114 No Immunogenetics Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Anahita Nosrati anahita785@gmail.com 10031947532846007115 10031947532846007115 No Department of Pathology, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran. Seyed Abdollah Mousavi dr.a.mosavi@gmail.com 10031947532846007116 10031947532846007116 No Department of Pediatric Surgery, Pediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran. Mohammad Naderisorki dr.naderisorki@gmail.com 10031947532846007117 10031947532846007117 Yes Thalassemia Research Center (TRC), Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran.