en Pediatric Endocrinology Narrative Review Narrative Review <strong>Background</strong>: COVID-19 is an unknown and novel virus that creates a challenge with all comorbid conditions, including diabetes mellitus (DM). Although DM has not been determined as a definite risk factor for COVID-19 in childhood, clinicians should consider the potential association between DM and COVID-19.&nbsp;<br> <strong>Objectives</strong>: This study aimed to review COVID-19 and DM comorbidity in children.<br> Methods: ISI Web of Science, PubMed, and Google Scholar were investigated to find relevant articles regarding COVID-19 and DM.<br> <strong>Results</strong>: Data revealed 50% higher fatal outcomes of COVID-19 in DM children than in healthy ones. Because of the importance of DM in children, it seems mandatory to consider type 1 diabetes and its consequences on COVID-19.<br> <strong>Conclusions</strong>: Understanding the pathophysiology of COVID-19 and its interaction with DM are helpful for better management of the disease. These considerations can help clinicians make better decisions about the treatment modalities, management, and diabetic ketoacidosis treatment. COVID-19, Child, Diabetes mellitus 397 402 http://jpr.mazums.ac.ir/browse.php?a_code=A-10-584-3&slc_lang=en&sid=1 Mahin Hashemipour hashemipour@mui.ac.ir 10031947532846007955 10031947532846007955 No Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Daniel Zamanfar danielzamanfar@ymail.com 10031947532846007956 10031947532846007956 No Diabetes Research Center, Department of Pediatric Endocrinology, Mazandaran University of Medical Sciences, Sari, Iran. Houman Hashemian hashemian@gums.ac.ir 10031947532846007957 10031947532846007957 No Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. Afagh Hassanzadeh Rad afaghrad@gums.ac.ir 10031947532846007958 10031947532846007958 No Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. Maryam Shahrokhi shahrokhi.mail85@gmail.com 10031947532846007959 10031947532846007959 No Department of clinical pharmacy, Faculty of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran. Setila Dalili setiladalili1346@yahoo.com 10031947532846007960 10031947532846007960 Yes Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.