en Pediatric Gastroenterology Systematic Review Systematic Review <div style="text-align: justify;"><strong>Background</strong>: Considering the chronic immunosuppression in inflammatory bowel disease (IBD) patients, it is necessary to evaluate the course of COVID-19 in these patients. Studies have shown various results in adult IBD patients. This study aimed to find out the course of this infection in pediatric IBD patients.&nbsp;<br> <strong>Methods</strong>: This was a systematic review study according to the PRISMA 2020 guideline. International databases including Scopus, PubMed, and the Web of Science were searched with a combination of &ldquo;COVID-19&rdquo; AND &ldquo;IBD&rdquo; or synonyms until October 16, 2021. Studies that have reported the outcomes of COVID-19 infection in patients less than 19 years of age were selected. Name of author, country, study duration and type, IBD type and drugs, and COVID-19 outcomes were extracted.<br> <strong>Results</strong>: From the initially retrieved 2215 articles, finally 16 articles were eligible. Data from 1040 pediatric IBD patients were reported. Twenty-four patients were hospitalized, 5 developed patients multisystem inflammatory syndrome in children, and others had a mild disease course and were outpatient. Steroid use, severe IBD activity, and comorbidities were shown to increase risk of hospitalization and disease severity.<br> <strong>Conclusion</strong>: COVID-19 is a benign and self-limited disease in pediatric IBD patients. Comorbidities, steroid use, and severe IBD activity affect the outcomes.</div> Coronavirus disease 2019, Inflammatory bowel disease, SARS-CoV-2, Pediatrics 277 286 http://jpr.mazums.ac.ir/browse.php?a_code=A-10-1059-1&slc_lang=en&sid=1 Peiman Nasri peiman94157@gmail.com 10031947532846009896 10031947532846009896 No Metabolic Liver Disease Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Somayeh Sadeghi s.sadeghi117917@gmail.com 10031947532846009897 10031947532846009897 No Acquired Immunodeficiency Research Center, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran. Silva Hovsepian silvahovsepsecret@gmail.com 10031947532846009898 10031947532846009898 No Metabolic Liver Disease Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Rojin Chegini rojin_chegini@yahoo.com 10031947532846009899 10031947532846009899 No Metabolic Liver Disease Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Shahrzad Soltani Esmaeili shahrzad.soltani71@yahoo.com 10031947532846009900 10031947532846009900 No Department of Pediatrics, School of Medicine, Imam Hossein Children’s Hospital, Isfahan University of Medical Sciences, Isfahan, Iran. Gelareh Kiani goli2291@yahoo.com 10031947532846009901 10031947532846009901 Yes Department of Pediatrics, School of Medicine, Imam Hossein Children’s Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.