en آلرژی و ایمونولوژی بالینی Allergy and Clinical Immunology Review Article Review Article <strong>Background</strong>: Prevalence of obesity and asthma have increased recently, likely due to the transition to a westernized lifestyle and urbanization. Obesity can increase the risk of asthma.&nbsp;<br> <strong>Objectives</strong>: This study aimed to investigate the co-occurrence of asthma and obesity in children referring to pediatric clinics in Hamadan, Iran, in 2007 and 2018.<br> <strong>Methods</strong>: This is a correlational study with a cross-sectional design that was conducted in 2007 (phase I) and in 2018 (phase II) in Hamadan, Iran. In phase I, participants were 101 children with asthma aged 1-12 were referred to Ekbatan Hospital. In phase II, participants were 100 children with asthma aged 1-16 referred to Besat Hospital. Their information, including age, body mass index (BMI), and family history, was recorded in two phases.<br> <strong>Results</strong>: Among participants, 61.4% in the first phase and 60% in the second phase were male. The mean age of children in the first and second phases was 4.45&plusmn;2.72 and 7.19&plusmn;3.47 years, respectively. It was found that 31.7% of children in the first phase and 33.3% in the second phase were obese. Although a high BMI is a risk factor for asthma, most children had a normal weight in both phases. Therefore, it can be said that obesity is not related to asthma.<br> <strong>Conclusions</strong>: The findings do not support the association of obesity with asthma in children. Further studies with a prospective design and a larger sample size are recommended to investigate this relationship more thoroughly. Asthma, Obesity, Children, Body mass index (BMI) 325 330 http://jpr.mazums.ac.ir/browse.php?a_code=A-10-1078-1&slc_lang=en&sid=1 Mojgan Safari mojgan.safaei@umsha.ac.ir 100319475328460013032 100319475328460013032 Yes Department of Allergy and Immunology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.