en نوزادان Neonatology Review Article Review Article <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Tahoma;"><span style="line-height:2;"><strong>Background</strong>: The most common symptoms in neonates with severe COVID-19 infection have been respiratory problems. The virus may adversely affect organs such as the liver.&nbsp;<br> <strong>Methods</strong>: Studies focusing solely on liver involvement in newborns with COVID-19 infection were searched in Pubmed, Scopus, and Google Scholar databases. Eight studies were finally reviewed.<br> <strong>Results</strong>: Direct viral invasion (COVID-19-induced hepatitis or systemic inflammatory response) and drug-induced may contribute to liver damage in neonates. SARS-CoV-2 may be the latest spark in toxoplasmosis, other agents, rubella, cytomegalovirus, herpes infections, and fetal liver involvement may be induced by transplacental transmission.&nbsp;<br> <strong>Conclusions</strong>: Hepatic dysfunction is infrequent but important in neonates with COVID-19 infection and the mechanism of liver damage associated with COVID-19 may differ from that in adults.</span></span></span></div> COVID-19, Hepatitis, Liver diseases, Newborn, SARS-CoV-2, Transaminases 125 134 http://jpr.mazums.ac.ir/browse.php?a_code=A-10-47-4&slc_lang=en&sid=1 Roya Farhadi rfarhadi@mazums.ac.ir 10031947532846009544 10031947532846009544 Yes Pediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran.