en Pediatrics Review Article Review Article <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Tahoma;"><span style="line-height:2;"><strong>Background</strong>: Phototherapy is the most common treatment of neonatal jaundice that affects the zinc level as well as the bilirubin level.<br> Objectives: The purpose of this study is to investigate the effect of phototherapy on the zinc level of infants with jaundice by a systematic review and meta-analysis.<br> <strong>Methods</strong>: In this systematic review and meta-analysis a comprehensive literature search of the databases, including Cochrane Library, Web of Science, PubMed, Scopus, and Google Scholar web browser was conducted using standard keywords. Data analysis of this meta-analysis was performed using STATA software, version 14 and P<0.05 was considered a significant level for tests.&nbsp;<br> <strong>Results</strong>: In the five studies reviewed in this article with a sample size of 398 individuals, phototherapy increased the level of zinc [Standardized mean difference (SMD): 0.88 (95% CI: 0.38, 1.38), P<0.001] and decreased bilirubin level [SMD: -7.67 (95% CI: -9.11, -6.23), P<0.001] in infants with jaundice. The effect of phototherapy was on the zinc level of these groups: infants with a birth weight of 3000 to 3300 grams (gr) [SMD: 1.07 (95% CI: 0.42, 1.71), P<0.001] and 3301 to 3600 gr [SMD: 0.40 (95% CI: -0.32, 1.12), P=0.028], three-day-old infants [SMD: 1.05 (95% CI: 0.35, 1.74), P<0.001], four-day-old [SMD: 0.76 (95% CI: 0.26, 1.32)], and 5-day-old ones [SMD: 0.23 (95% CI: -0.01, 0.48)]. In addition, phototherapy affected on zinc level of those whose gestational age (GA) was 37 [SMD: 1.12 (95% CI: 0.06, 2.17), P<0.001] and 38 [SMD: 0.61 (95% CI: 0.15, 1.06), P=0.001] weeks.<br> <strong>Conclusions:</strong> Phototherapy by reducing the level of bilirubin increases the level of zinc in infants with jaundice. So, the standardized mean difference of &ldquo;phototherapy effects on the zinc level of infants with jaundice&rdquo; decreases with increasing infants&rsquo; weight, increasing infants&rsquo; age, and increasing gestational age.</span></span></span></div> Zinc, Hyperbilirubinemia, Neonatal jaundice, Jaundice, Neonatal, Phototherapy, Light therapy 107 116 http://jpr.mazums.ac.ir/browse.php?a_code=A-10-1047-4&slc_lang=en&sid=1 Diana Sarokhani diana_sarokhani@yahoo.com 10031947532846009537 10031947532846009537 No Research Center for Environmental Determinants of Health, School of Public Health, Kermanshah University of Medical Sciences, Kermanshah, Iran. Amir Adibi amir771155@yahoo.com 10031947532846009538 10031947532846009538 No Department of Child and Adolescent Psychiatry, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran. Mohsen Abdan mohsen_abdan@yahoo.com 10031947532846009539 10031947532846009539 No Research Center for Environmental Determinants of Health, School of Public Health, Kermanshah University of Medical Sciences, Kermanshah, Iran. Moloud Fakhri mmfir@yahoo.com 10031947532846009540 10031947532846009540 Yes Traditional and Complementary Medicine Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran.