en نفرولوژی کودکان Pediatric Nephrology Systematic Review Systematic Review <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Tahoma;"><span style="line-height:2;"><strong>Background</strong>: Identifying affecting and predictive factors of steroid-sensitive nephrotic syndrome&rsquo;s (SSNS&#39;s) outcome may greatly benefit the proper management of SSNS patients.&nbsp;<br> <strong>Objectives</strong>: The current systematic review comprehensively reviews all available evidence on the risk factors of SSNS relapse in children and adolescents.&nbsp;<br> <strong>Methods</strong>: An extensive search was conducted on the electronic databases of Medline, Embase, Web of Science, and Scopus until February 18, 2024. Studies investigating the risk factors of relapse were included in this systematic review.<br> <strong>Results</strong>: A total of 11 articles were included. Age, gender, and laboratory variables, such as serum creatinine and serum protein are not risk factors for relapse in these studies. Possible associations were reported for risk factors, such as the number of relapses and response time. Overall, the studies reported conflicting results on the value of relapse risk factors.<br> <strong>Conclusions</strong>: Although factors, such as hematuria, hypertension, time from treatment to response, and number of relapses have been proposed as possible risk factors for relapse, no conclusion can be reached due to the heterogeneity of studies. Future studies should have more conforming designs to make comparisons more reliable.</span></span></span></div> Nephrotic syndrome, Steroi-sensitive nephrotic syndrome (SSNS), Risk factor, Recurrence 153 170 http://jpr.mazums.ac.ir/browse.php?a_code=A-10-1190-1&slc_lang=en&sid=1 Mahmoud Yousefifard yousefifard20@iums.ac.ir 100319475328460011308 100319475328460011308 No Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran. Koohyar Ahmadzadeh koohyar.ahmadzadeh@gmail.com 100319475328460011309 100319475328460011309 No Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran. Arian Madani Neishaboori arian.md7@gmail.com 100319475328460011310 100319475328460011310 No Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran. Seyedeh Niloufar Rafiei Alavi niloufar.raf@hotmail.com 100319475328460011311 100319475328460011311 No Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran. Seyedeh Romina Rafiei Alavi romina.rafiei@gmail.com 100319475328460011312 100319475328460011312 No Department of Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Hooman Ahmadzadeh hooman.ahmadzadeh@gmail.com 100319475328460011313 100319475328460011313 No Department of Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Amirmohammad Toloui toloui.amir@gmail.com 100319475328460011314 100319475328460011314 No Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran. Mohammed I M Gubari mohammed.jubari@gmail.com 100319475328460011315 100319475328460011315 No Department of Community Medicine, College of Medicine, University of Sulaimani, Sulaimani, Iraq. Michael E. Jones Michael.Jones@icr.ac.uk 100319475328460011316 100319475328460011316 No Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK. Nematollah Ataei ataei_nm@yahoo.com 100319475328460011317 100319475328460011317 No Pediatrics Chronic Kidney Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran. Mojtaba Fazel Mojtabafazel@yahoo.com 100319475328460011318 100319475328460011318 No Pediatrics Chronic Kidney Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran. Mostafa Hosseini mhossein110@yahoo.com 100319475328460011319 100319475328460011319 Yes Pediatrics Chronic Kidney Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran.