Volume 7, Issue 4 (10-2019)                   J. Pediatr. Rev 2019, 7(4): 211-216 | Back to browse issues page


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1- Department of Obsobstetrics & Gynecology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
2- Department of Immunology, School of Medicine, Pediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran. , siamakdabbaghzade@yahoo.com
Abstract:   (4760 Views)
Context: Asthma is a chronic inflammatory disorder of the respiratory system in children. Immunoglobulin E (IgE) has an important role in allergic disorders like asthma. This study aimed to review the association between maternal serum IgE and the incidence of childhood asthma.
Evidence Acquisition: Three researchers searched all articles in PubMed, Scopus, Google, and Embase databases related to maternal serum IgE, cord blood IgE, childhood asthma, and its incidence. We used keywords such as “maternal IgE, cord blood IgE, relation, association, childhood asthma, and child allergy”. 
Results: We found a few related articles on maternal IgE, cord blood IgE, and childhood asthma. In total, we reviewed 11 articles. Parental atopy and allergy are the most important predictive factors for children’s allergies, like asthma. IgE levels were higher in children whose mothers had higher IgE levels. Total IgE level was significantly higher in boys, compared to girls. 
Conclusions: Increased maternal and cord blood IgE may be a predictive factor for the development of childhood asthma. More data are required to clarify this relationship. 
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Type of Study: Narrative Review | Subject: Allergy and Clinical Immunology
Received: 2018/09/26 | Accepted: 2018/11/21 | Published: 2019/10/1

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