Volume 9, Issue 2 (4-2021)                   J. Pediatr. Rev 2021, 9(2): 159-162 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Karami H, Naderisorki M, Ghasemi M, Ghazaiean M. Pancytopenia as a Presentation of Iron Deficiency: A Case Report. J. Pediatr. Rev 2021; 9 (2) :159-162
URL: http://jpr.mazums.ac.ir/article-1-358-en.html
Pancytopenia as a Presentation of Iron Deficiency: A Case Report
Hossein Karami1 , Mohammad Naderisorki 2, Maryam Ghasemi3 , Mobin Ghazaiean4
1- Thalassemia Research Center (TRC), Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran.
2- Thalassemia Research Center (TRC), Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran. , dr.naderisorki@gmail.com
3- Immunogenetics Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
4- Student Research Committe, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Abstract:   (3741 Views)
One of the most common nutritional deficiencies worldwide is iron deficiency. Fatigue, pallor, vertigo, dyspnea, cold intolerance, lethargy, palpitation, headache, and the pallor of the mucous membranes or nail beds are the most frequent symptoms and signs of iron deficiency. Thrombocytosis is commonly observed in iron deficiency anemia; it seems that erythropoietin plays the main role in this respect. Furthermore, thrombocytopenia and even leukopenia have been reported in iron deficiency; however, pancytopenia is a very rare condition. In this report, we presented two unusual cases of pancytopenia due to severe iron deficiency that improved after treatment with oral iron supplements. Iron deficiency anemia, if sufficiently severe, may be associated with reduced platelet and leukocyte counts. Accordingly, this condition should be considered as a differential diagnosis in all patients with pancytopenia.
Keywords: Pancytopenia, Iron deficiency, Anemia
Full-Text [PDF 1471 kb]   (2279 Downloads) |   |   Full-Text (HTML)  (857 Views)  
Type of Study: Case Report and Review of Literature | Subject: Pediatrics
Received: 2020/09/18 | Accepted: 2020/10/6 | Published: 2021/04/1
References
1. Kassebaum NJ, Jasrasaria R, Naghavi M, Wulf SK, Johns N, Lozano R, et al. A systematic analysis of global anemia burden from 1990 to 2010. Blood. 2014;123(5):615-24. [DOI:10.1182/blood-2013-06-508325] [PMID] [PMCID]
2. Camaschella C. Iron deficiency. Blood. 2019;133(1):30-9. [DOI:10.1182/blood-2018-05-815944] [PMID]
3. Stohlawetz PJ, Dzirlo L, Hergovich N, Lackner E, Mensik C, Eichler HG, et al. Effects of erythropoietin on platelet reactivity and thrombopoiesis in humans. Blood. 2000;95(9):2983-9. [DOI:10.1182/blood.V95.9.2983.009k27_2983_2989] [PMID]
4. Ganti AK, Shonka NA, Haire WD. Pancytopenia due to iron deficiency worsened by iron infusion: a case report. Journal of Medical Case Reports. 2007;1(1):175. [DOI:10.1186/1752-1947-1-175] [PMID] [PMCID]
5. Lim Y, Lee EY, Choi IS, Kim T-Y, Yoon S-S, Kim KH. Leukopenia in Patients with Iron Deficiency Anemia. Blood. 2011;118(21):5279-. [DOI:10.1182/blood.V118.21.5279.5279]
6. Jhamb R, Kumar A. Iron deficiency anemia presenting as pancytopenia in an adolescent girl. International journal of adolescent medicine and health. 2011;23(1):73-4. [DOI:10.1515/ijamh.2011.012] [PMID]
7. Özdemir N. Iron deficiency anemia from diagnosis to treatment in children. Turk pediatri arsivi. 2015;50(1):11-9. [DOI:10.5152/tpa.2015.2337] [PMID] [PMCID]
8. Anderson C, Aronson I, Jacobs P. Erythropoiesis: Erythrocyte Deformability is Reduced and Fragility increased by Iron Deficiency. Hematology (Amsterdam, Netherlands). 2000;4(5):457-60. [DOI:10.1080/10245332.1999.11746471] [PMID]
9. Orkin SH, Fisher DE, Ginsburg D, Look AT, Lux SE, Nathan DG. Nathan and Oski's hematology and oncology of infancy and childhood. 2015.
10. Morris VK, Spraker HL, Howard SC, Ware RE, Reiss UM. SEVERE THROMBOCYTOPENIA WITH IRON DEFICIENCY ANEMIA. Pediatric Hematology and Oncology. 2010;27(5):413-9. [DOI:10.3109/08880011003739455] [PMID] [PMCID]
11. McDonald TP, Clift RE, Cottrell MB. Large, chronic doses of erythropoietin cause thrombocytopenia in mice. Blood. 1992;80(2):352-8. https://doi.org/10.1182/blood.V80.2.352.352 [DOI:10.1182/blood.V80.2.352.bloodjournal802352] [PMID]
12. Ibrahim R, Alhilli JA, Cooper TT, Dashkova I, Guy J, Gandhi A, et al. Idiopathic Thrombocytopenia with Iron Deficiency Anemia. Clinical Medicine Insights: Blood Disorders. 2013;6:CMBD.S11371. [DOI:10.4137/CMBD.S11371] [PMID] [PMCID]
13. Christensen RD, Liechty KW, Koenig JM, Schibler KR, Ohls RK. Administration of erythropoietin to newborn rats results in diminished neutrophil production. Blood. 1991;78(5):1241-6. https://doi.org/10.1182/blood.V78.5.1241.bloodjournal7851241 [DOI:10.1182/blood.V78.5.1241.1241] [PMID]
14. Avneon M, Lifshitz L, Katz O, Prutchi-Sagiv S, Gassmann M, Mittelman M, et al. Non-erythroid effects of erythropoietin: are neutrophils a target? Leukemia research. 2009;33(10):1430-2. [DOI:10.1016/j.leukres.2009.03.020] [PMID]
15. Auerbach M, Adamson JW. How we diagnose and treat iron deficiency anemia. American journal of hematology. 2016;91(1):31-8. [DOI:10.1002/ajh.24201] [PMID]
16. Ning S, Zeller MP. Management of iron deficiency. Hematology American Society of Hematology Education Program. 2019;2019(1):315-22. [DOI:10.1182/hematology.2019000034] [PMID] [PMCID]
17. Susanne van S, Quirijn de M, Janine DO, Annelies van E, Dorine WS, André JAMvdV. Hematologic parameters predicting a response to oral iron therapy in chronic inflammation. Haematologica. 2014;99(9):e171-e3. [DOI:10.3324/haematol.2014.106799] [PMID] [PMCID]
Add your comments about this article : Your username or Email:
CAPTCHA
Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Journal of Pediatrics Review

Designed & Developed by : Yektaweb