Journal of Pediatrics Review
Journal of Pediatrics Review
J. Pediatr. Rev
Medical Sciences
http://jpr.mazums.ac.ir
1
admin
2322-4398
2322-4401
10.32598
en
jalali
1394
4
1
gregorian
2015
7
1
3
2
online
1
fulltext
en
Allgrove’s Syndrome: Two Case Reports and Review of Literature
Case & Review
Case & Review
<aside>
<p><b>Introduction:</b> Allgrove’s syndrome (AS) is a rare cause of adrenal insufficiency inherited in an autosomal recessive pattern. Usually the disease is manifested during the first decade of life with severe hypoglycaemia, which can lead to sudden death.</p>
</aside>
<aside>
<p><b>Case Presentation:</b> Here we described two cases of Allgrove’s syndrome; the first case was an 8-year-old male admitted to hospital for evaluation of seizure and gait abnormality and the second case was a 4-year-old boy admitted for evaluation of hyperpigmentation of his skin and buccal mucosa for eight months, also we made a review of literature.</p>
</aside>
<aside>
<p><b>Conclusions:</b> Alacrima is considered to be the earliest clinical manifestation of Triple A syndrome and early recognition of glucocorticoid deficiency would prevent hypoglycaemic convulsions, neurological sequelae and death. A carful replacement of glucocorticoids is critical to avoid adrenal crisis and allow normal growth and development.</p>
</aside>
Syndrome, Adrenal Insufficiency, Alacrima, Case Report
48
52
http://jpr.mazums.ac.ir/browse.php?a_code=A-10-30-35&slc_lang=en&sid=1
Daniel
Zamanfar
10031947532846001099
10031947532846001099
Yes
Elika
Shokri
10031947532846001100
10031947532846001100
No
Shiva
Shadani
10031947532846001101
10031947532846001101
No
Soheila
Shahmohammadi
10031947532846001102
10031947532846001102
No