Journal of Pediatrics Review
Journal of Pediatrics Review
J. Pediatr. Rev
Medical Sciences
http://jpr.mazums.ac.ir
1
admin
2322-4398
2322-4401
10.32598
en
jalali
1395
10
1
gregorian
2017
1
1
5
1
online
1
fulltext
en
Factors Associated with Newly Diagnosed Children with Diabetic Ketoacidosis
Original Article
Original Article
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<p style="box-sizing: border-box; margin: 0px 0px 10px; text-align: justify;"><b style="box-sizing: border-box;">Background:</b> Diabetes mellitus type 1 is one of the most prevalent endocrine diseases in pediatrics. Diabetic ketoacidosis is considered as one of the most threatening clinical pictures of DM1, especially if occurred as the first presentation of DM1 in children.</p>
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<p style="box-sizing: border-box; margin: 0px 0px 10px; text-align: justify;"><b style="box-sizing: border-box;">Objectives:</b> The current study aimed to identify factors which may play a role in DKA onset in children.</p>
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<p style="box-sizing: border-box; margin: 0px 0px 10px; text-align: justify;"><b style="box-sizing: border-box;">Methods:</b> This case-control study included all patients under 18 years old who referred to department of pediatrics endocrinology at Mashhad University Hospital (Imam Reza) from January 2013 to December 2015 as newly diagnosed patients with DM1. Patients who fulfilled DKA criteria at diagnosis were considered as DKA group and those who referred with other presentations were considered as control group (non-DKA group). Data were analyzed by SPSS software ver. 16.</p>
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<p style="box-sizing: border-box; margin: 0px 0px 10px; text-align: justify;"><b style="box-sizing: border-box;">Results:</b> During the study period, 97 (39.2% male) newly diagnosed patients were included as DKA group. Accordingly 97 gender- and age-matched patients were added as non-DKA group. The most prevalent symptoms in both groups were polyuria (91.88%) and polydipsia (88.66%). Fever and cold symptoms were significantly higher in the DKA group (P < 0.001 and P =0.005, respectively). Hemoglobin A1c level was significantly higher in the DKA group (P = 0.001), while body mass index was significantly lower in the DKA group (P = 0.045). Fever and father’s education level were the most important risk and protective factors in the DKA onset in newly diagnosed patients with DM1 (adjusted OR = 10.1, 95% CI = 2.9-35.3; P < 0.001 and adjusted OR = 0.5, 95% CI = 0.3 - 0.9 and P = 0.019, respectively).</p>
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<p style="box-sizing: border-box; margin: 0px 0px 10px; text-align: justify;"><b style="box-sizing: border-box;">Conclusions:</b> In conclusion, a recent febrile illness was found as the strongest risk factor and father’s education level as the main protective factor in the DKA to diagnose children with DM1. The study findings suggested that DKA is a severe form of DM1 instead of a neglected or misdiagnosed disease.</p>
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Children, Diabetic Ketoacidosis, Diabetes Mellitus Type 1
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71
http://jpr.mazums.ac.ir/browse.php?a_code=A-10-30-63&slc_lang=en&sid=1
Raheleh
Mirsadraee
10031947532846002268
10031947532846002268
No
Department of Pediatric Endocrinology and Metabolism, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran
Mohamad
Khajedaluee
10031947532846002269
10031947532846002269
No
Department of Community Medicine, University of Medical Sciences, Mashhad, IR Iran
Rahim
Vakili
hosseiny.samane@gmail.com
10031947532846002270
10031947532846002270
Yes
Medical Genetic Research Center, Department of Human Genetics, Imam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran; Department of Community Medicine, University of Medical Sciences, Mashhad, IR Iran
Azam
Hasanabade
10031947532846002271
10031947532846002271
No
Department of Community Medicine, University of Medical Sciences, Mashhad, IR Iran
Zahra
Saeedrezaee
10031947532846002272
10031947532846002272
No
Department of Community Medicine, University of Medical Sciences, Mashhad, IR Iran