Impact of Maternal Folate Deficiencies on Early Neurological Development: A Narrative Review

Emmerson, Joshua T; Jadavji , Nafisa M

doi:10.17795/jpr-6174.

Volume 4, Issue 2 (7-2016) J. Pediatr. Rev 2016, 4(2): 52-57 | Back to browse issues page

‎ 10.17795/jpr-6174.

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Emmerson J T, Jadavji N M. Impact of Maternal Folate Deficiencies on Early Neurological Development: A Narrative Review . J. Pediatr. Rev 2016; 4 (2) :52-57
URL: http://jpr.mazums.ac.ir/article-1-129-en.html

Impact of Maternal Folate Deficiencies on Early Neurological Development: A Narrative Review

Joshua T Emmerson¹

, Nafisa M Jadavji

1- Department of Neuroscience, Carleton University, Ottawa, Canada
2- Department of Neuroscience, Carleton University, Ottawa, Canada , nafisa.jadavji@mail.mcgill.ca

Abstract: (3583 Views)

Context: Folates are B-vitamins that cannot be generated de novo and are therefore obtained from the diet. In the brain, these vitamins are involved in nucleotide synthesis, DNA repair, lipid metabolism, methylation and neurotransmitter synthesis. It is well established that adequate levels of maternal folates are required for closure of the neural tube within the first month of pregnancy, however, it is not clear whether maternal folates are needed throughout pregnancy for brain development and whether they influence offspring neurological function after birth. The aim of this review is to outline current literature from epidemiological and animal model studies that shows maternal supplementation of folates throughout pregnancy does indeed affect offspring neurological function after birth.

Keywords: Embryology, Folic Acid, Maternal Fetal Exchange, Methylenetetrahydrofolate Reductase (MTHFR), Neuologic Manifestations, Offspring Neurological Model

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Type of Study: Narrative Review |
Received: 2016/03/30 | Accepted: 2016/06/29 | Published: 2016/07/23

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