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1- Department of Immunology and Allergy, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
2- Department of Allergy and Clinical Immunology, Allergy Research Center, Mashhad
3- Department of Allergy and Clinical Immunology, Allergy Research Center, Mashhad , arc@mums.ac.ir
Abstract:   (278 Views)
Introduction: Common Variable Immunodeficiency (CVID) is one of the primary immunodeficiencies that affected patients can develop symptoms from infancy through to senescence (any age); however, it is usually between the age of 15 and 40 years. It is characterized due to low antibody levels and recurrent infections. This makes an individual more prone to autoimmune diseases and malignancy as well.
Case Presentation: We present a 17-year-old girl with a documented CVID, who was treated with Intra Venous Immunoglobulin (IVIG) and prophylactic antibiotics, has had this disease since she was 13 years old up to now. She hospitalized with illness, fever and severe dyspnea. Chest X-ray showed cardiomegaly so high-resolution thorax CT scan and Echocardiography were done and revealed pericardial effusion. In our assessments, we did not find any underlying autoimmune disease. The significant clinical, radiographic and physiological improvements were achieved after an appropriate therapy. The patient has been followed for two years and still has no clinical and laboratory findings for autoimmune diseases. In our case, it is interesting that the pericardial effusion was present without any evidence of autoimmunity.
Conclusion:  Cardiac manifestation and complications are not so common in CVID patients in the absence of an autoimmune disease, but it should be considered.
Full-Text [PDF 560 kb]   (76 Downloads)    
Type of Study: Case & Review | Subject: Immunology
Received: 2018/05/13 | Accepted: 2018/08/18

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