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Volume 8, Issue 1 (1-2020)
J. Pediatr. Rev 2020, 8(1): 29-34 |
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Abolhassan Choobdar F, Milani H, Behrouzi K, Khalesi N, Haghighi B, Manafi A, et al . Anti-Rh17 Alloimmunization: A Rare Case of Severe Hemolytic Disease of the Newborn and Review of the Literature. J. Pediatr. Rev 2020; 8 (1) :29-34
URL: http://jpr.mazums.ac.ir/article-1-216-en.html
URL: http://jpr.mazums.ac.ir/article-1-216-en.html
Farhad Abolhassan Choobdar1 
, Hani Milani *2 , Kamran Behrouzi3 , Nasrin Khalesi1 , Behzad Haghighi4 , Ali Manafi4 , Mohammad Naderisorki5 , Sorraya Shojaee1
, Hani Milani *2 , Kamran Behrouzi3 , Nasrin Khalesi1 , Behzad Haghighi4 , Ali Manafi4 , Mohammad Naderisorki5 , Sorraya Shojaee1
1- Department of Neonatology, Aliasghar Children Hospital, Iran University of Medical Sciences, Tehran, Iran.
2- Department of Neonatology, Kamali Hospital, Alborz University of Medical Sciences, Karaj, Iran. ,h.milani@abzums.ac.ir
3- Department of Neonatology, Kamali Hospital, Alborz University of Medical Sciences, Karaj, Iran.
4- Department of Pediatric Intensive Care, Aliasghar Children Hospital, Iran University of Medical Sciences, Tehran, Iran.
5- Thalassemia Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
2- Department of Neonatology, Kamali Hospital, Alborz University of Medical Sciences, Karaj, Iran. ,
3- Department of Neonatology, Kamali Hospital, Alborz University of Medical Sciences, Karaj, Iran.
4- Department of Pediatric Intensive Care, Aliasghar Children Hospital, Iran University of Medical Sciences, Tehran, Iran.
5- Thalassemia Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Abstract: (6321 Views)
Background: ABO/Rh incompatibilities are common causes of hemolytic disease of newborn. Alloimmunization due to minor RBC antigens may also cause severe hemolysis and hyperbilirubinemia necessitating exchange transfusion in the early neonatal period.
Case Presentation: Here we report a rare case (first such report to our knowledge in Iran) of severe hemolytic disease of the newborn due to anti-Rh17 antibody (an antibody to the RhCc/Ee antigen protein) in a newborn with maternal blood group B Rh D--.
Conclusion: Presenting this case would improve the insight and knowledge about managing severe hemolytic anemia due to minor group alloantibodies postnatally, and highlight the importance of prenatal surveillance and diagnosis for the optimal management of alloimmune hemolytic disease.
Case Presentation: Here we report a rare case (first such report to our knowledge in Iran) of severe hemolytic disease of the newborn due to anti-Rh17 antibody (an antibody to the RhCc/Ee antigen protein) in a newborn with maternal blood group B Rh D--.
Conclusion: Presenting this case would improve the insight and knowledge about managing severe hemolytic anemia due to minor group alloantibodies postnatally, and highlight the importance of prenatal surveillance and diagnosis for the optimal management of alloimmune hemolytic disease.
Type of Study: Case Report and Review of Literature |
Subject:
Pediatric Hematology and Oncology
Received: 2018/12/3 | Accepted: 2019/07/21 | Published: 2020/01/1
Received: 2018/12/3 | Accepted: 2019/07/21 | Published: 2020/01/1
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