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1- Department of Neonatology, Iran University of Medical Sciences, Aliasghar Children Hospital, Tehran, Iran
2- Department of Neonatology, Alborz University of Medical Sciences, Kamali Hospital, Karaj, Iran , h.milani@abzums.ac.ir
3- Department of Neonatology, Alborz University of Medical Sciences, Kamali Hospital, Karaj, Iran
4- Department of Pediatric Intensive Care, Iran University of Medical Sciences, Aliasghar Children Hospital, Tehran, Iran
5- Thalassemia Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Abstract:   (137 Views)
Background: ABO/Rh incompatibilities are common causes of hemolytic disease of newborn (HDN). Alloimmunization due to minor RBC antigens may also cause severe hemolysis and hyperbilirubinemia necessitating exchange transfusion in early neonatal period.
Case presentation: Here we report a rare case (first such report to our knowledge in Iran), of severe hemolytic disease of the newborn due to anti-Rh17 antibody (an antibody to the RhCc/Ee antigen protein), in a newborn with maternal blood group B Rh D--.
Conclusion: This case would improve the insight and knowledge about managing severe hemolytic anemia due to minor group alloantibodies postnatally, and highlight the importance of prenatal surveillance and diagnosis for the optimal management of alloimmune hemolytic disease.
 
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Type of Study: Case Report and Review of Literature | Subject: Pediatric Hematology and Oncology
Received: 2018/12/3 | Accepted: 2019/07/21

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