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1- Pediatric infectious diseases research center, Mazandaran University of medical sciences, Sari, Iran
2- Pediatric infectious diseases research center, Mazandaran University of medical sciences, Sari, Iran , javadneg@yahoo.com
3- Community Medicine Specialist, Education Development Center, Mazandaran University of medical sciences, Sari, Iran
4- Gastrointestinal cancer research center, Mazandaran University of medical sciences, Sari, Iran 5Pediatrician, Mazandaran University of medical sciences, Sari, Iran
Abstract:   (700 Views)
Background: Immune thrombocytopenia (ITP) is an autoimmune disorder associated with decreased platelet production and accelerated platelet destruction. An impaired immune system may induce and/or be associated with ITP.
Objectives: The aim of this study was to evaluate complement and humeral immune systems in ITP.
Methods: we evaluated 30 children (under 19 years old) with acute and chronic ITP referred to a tertiary hospital compared to 30 healthy volunteers. We evaluated CBC with differentiation, serum immunoglobulins (IgG, IgE, IgM, IgA, IgG1, IgG2, IgG3, IgG4) by nephelometry; ASO titer by agglutination; CH50, C3, C4 by nephelometry; CD19 by flow cytometry, anti-tetanus antibody titer by ELISA along demographic data in a questionnaire
Results: Our findings showed humeral and complement components were normal in both patients and healthy groups but after using independent t-test, mean serum levels of IgM, IgE, IgG1, C3 and tetanus antibody levels were significantly different between the two groups, their levels being higher in the patient group.
Conclusion: Humoral and complementary immunodeficiency in these patients is unlikely. However, more studies with larger sample sizes are needed.
 
Full-Text [PDF 709 kb]   (219 Downloads)    
Type of Study: Original Article | Subject: Allergy and Clinical Immunology
Received: 2019/04/7 | Accepted: 2019/06/9

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