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1- Department of Pediatrics Gastroenterology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran
2- Department of Pediatrics, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran
3- Student Research Committee, Faculty of Nursing and Midwifery, Ilam University of Medical Sciences, Ilam, Iran , hamedtavan@gmail.com
Abstract:   (91 Views)
Context: The physiologic jaundice in neonates usually occurs during the first week of life. The main cause of this condition is increase in serum bilirubin due to heme catabolism. 
Objective: The aim of this study was to investigate the therapeutic role of zinc sulfate in Iranian newborns with hyperbilirubinemia by systematic review and meta-analysis.


Data Sources, Study Selection, and Data Extraction: This review was performed based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) protocol. The databases of ISI, Cochrane Library, Google Scholar, PubMed, and Scopus were independently searched by two researchers using MeSH keywords. The studies published in different regions of Iran from 2015 to 2018 were included. Data was analyzed using meta-analysis and STATA software. In order to determine the heterogeneity among the studies, Q and I2 indices were used.


Results: A total of 40 articles were found from which 5 studies with adequate quality entered the systematic review process. The results were assessed in intervention (zinc sulfate recipients) and comparison (without zinc sulfate treatment) groups. After the first day, total serum bilirubin level decreased 4.46 mg/dl (I2 = 61.9%, P=0.049) and 4.08 mg/dl (I2 =72.9%, P = 0.011) in the intervention and comparison groups respectively. At the second and third days, the means of decreases in serum bilirubin reached 7.64 mg / dl and 6.66 mg / dl in the intervention and comparison groups respectively. From the third day on ward, serum bilirubin dropped by 8.46 and 7.08 mg / dl in intervention and comparison groups respectively.  Meta-regression analysis based on the sample size and year of study indicated a significant increasing trend in using zinc sulfate by increasing years and sample size.


Conclusion: Zinc sulfate is a safe and effective drug in reducing bilirubin level and its usage has increased in recent years. Therefore, this drug can be used in the treatment of neonatal hyperbilirubinemia.
Full-Text [PDF 683 kb]   (27 Downloads)    
Type of Study: Meta-analysis Review | Subject: Pediatric Gastroenterology
Received: 2019/05/25 | Accepted: 2019/10/26

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