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1- Department of Pediatric Infectious Diseases, Iran University of medical Sciences, Tehran, Iran
2- Department of Pediatric Nephrology, Iran University of medical Sciences, Tehran, Iran
3- Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
4- Department of Pediatric Gastroenterology, Iran University of medical Sciences, Tehran, Iran
5- Department of Pediatric Nephrology, Iran University of medical Sciences, Tehran, Iran , rozitahoseini@yahoo.com
Abstract:   (87 Views)
Background: One of the main problems following organ transplantation is the spread of various microbial infections, especially opportunistic infections such as Epstein-barr virus (EBV).
Objective: We aimed to determine the prevalence of EBV infection in children undergoing kidney transplantation by determining the titer of the virus before and after transplantation.
Methods: In this case series study, 16 children underwent kidney transplantation and hospitalized were retrospectively assessed. The EBV serology was assessed by virus DNA quantitative assessment using the Polymerase chain reaction (PCR) technique. A brief review was also performed on Post-kidney transplantation EBV infection in children.
Results: All patients were seronegative for EBV before transplantation, while two male children (12.5%) had positive serology after transplantation with the loads of 278copies/mL and 14655copies/Ml and none resulted in rejection of kidney transplantation. The duration after transplantation was significantly longer in those children with positive serology after transplantation (p = 0.025). no significant association was seen between the serological positivity for EBV and patients' gender, causes for kidney insufficiency before transplantation, baseline underlying disorders, initial medications, the type of donor, and the mean age.
Conclusion: Among our children undergoing renal transplantation, none were seropositive to EBV before transplantation, while 12.5% convert to EBV seropositivity after transplantation. The likelihood of EBV seropositivity was only linked to the time interval from the transplantation.
Full-Text [PDF 674 kb]   (47 Downloads)    
Type of Study: Original Article | Subject: Pediatric Infectious Diseases
Received: 2019/10/8 | Accepted: 2019/12/16

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