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1- ‎Department of Gynecology, Mazandaran University of Medical Sciences, Sari, Iran.
2- Pediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, ‎Sari, Iran. , javadneg@yahoo.com
3- Pediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, ‎Sari, Iran.
4- Beatson Institute for Cancer Research, Faculty of Medicine, University of Glasgow, Glasgow, ‎UK.
Abstract:   (110 Views)
Context: Asthma is a chronic inflammatory respiratory disorder. Nutritional conditions affect allergic disorders such as asthma. The aim of this study is to find the relationship between maternal gestational vitamin D levels and progression of asthma and wheezing in their children later in life. Allergic disorders are common everywhere the world. Asthma is the most chronic inflammatory respiratory disorder among children. Asthma causes significant morbidity and mortality in children as well as adults. Vitamin D deficiency or insufficiency is a worldwide problem. Vitamin D has an immunological effects and it may prevent autoimmune diseases. Maternal plasma vitamin D during pregnancy has different effects on the children allergic disorders.
Evidence Acquisition: This is a review article. We searched databases including Google scholar, PubMed, SID, Irandoc, Scopus and up-to-date. Key words for search include maternal vitamin D, asthma, wheezing, children and pediatric. We searched in mentioned data bases until on March 2020. Full text articles in English language were included in this study.
Results: A few articles were found in our searches. All of them were cohort studies. They evaluated maternal vitamin D and outcomes in their children`s asthma and wheezing using questionnaire data and serum samples. After evaluation of funded articles (more than 100), 15 paper include in our review. Six and four articles showed higher maternal vitamin D levels result in reduction of children’s asthma and or wheezing respectively. In contrast, seven and seven articles showed no association between maternal vitamin D and children’s asthma or wheezing respectively. Vitamin D does not have any serious side effects.  Because the articles were heterogenic, a meta-analysis could not be done.
Conclusions: Administering Vitamin D supplements or food enriched vitamin D during pregnancy has different effects on the prevalence of wheezing and or asthma in children.
Full-Text [PDF 1184 kb]   (40 Downloads)    
Type of Study: Narrative Review | Subject: Allergy and Clinical Immunology
Received: 2020/03/27 | Accepted: 2020/09/16

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