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1- Department of Pediatric Rheumatology, Shahid Beheshti University of Medical Sciences, ‎Tehran, Iran.‎
2- Department of Pediatric Rheumatology, Shahid Beheshti University of Medical Sciences, ‎Tehran, Iran.‎ , vadoodj@gmail.com
3- Department of Pediatric Rheumatology, Shahid Beheshti University of Medical Sciences, ‎Tehran, Iran.‎v
Abstract:   (93 Views)
Context: Henoch-Schonlein purpura is an important cause of chronic renal disease in children. This review identified some risk factors associated with renal involvement in childhood HSP.
 Evidence acquisition: Electronic databases such as Google Scholar, PubMed, and Scopus were searched using the following search terms: children, Henoch-Schönlein, risk factor, renal involvement, and IgA vasculitis. This review was designed to identify the relevant electronic studies published in the English language from December 1998 to August 2018.
 Results: This review revealed that clinically older age at presentation, persistent rash, atypical rash, rash on unusual location, and gastrointestinal bleeding were significant risk factors for renal involvement. In contrast, joint involvement was not associated with renal involvement.
Among biochemical markers, high RDW is a marker of the risk of renal involvement in HSP. In contrast, peripheral blood IgA, ANA, ASO titer, ESR, and CRP were not associated with renal involvement. Several studies have evaluated the role of WBC and platelet in increasing the risk of renal involvement. Leukocytosis, thrombocytosis, and/or thrombocytopenia have been mentioned as predictor factors for renal involvement in some studies, but other studies showed WBC and platelet are not risk factors.
The effect of corticosteroids as a predictive factor of renal involvement in HSP is challenging and controversial. Furthermore, their effect was dose-dependent.
Conclusion: Demographic factors, and clinical features, as well as some abnormal laboratory findings, are considerable predictive factors for renal involvement in HSP.
Full-Text [PDF 1361 kb]   (34 Downloads)    
Type of Study: Narrative Review | Subject: Pediatric Rheumatology
Received: 2020/05/31 | Accepted: 2020/09/28

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