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1- Clinical Pharmacist (ICU and ID), Clinical Pharmacy Services, Department of Pharmacy, Square Hospitals Ltd., Dhaka, Bangladesh. , jahidul@squarehospital.com
2- Matlab Health Research Centre, International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh.
Abstract:   (212 Views)
Background: Childhood diarrheal diseases are common with mild-to-severe mortality rate worldwide. Lower-middle-income countries (LMICs) including Bangladesh in South Asia are still unable to save their under-five lives due to diarrheal diseases in every year.
Objectives: The main objective of this study was to evaluate the duration of hospital stay and use of antibiotics in under-two children with moderate-diarrhea in Bangladesh.
Methods: This study was done on hospitalized 6 months to 2-year old 212 (N) pediatric patients with uncontrolled moderate type of diarrhea in 3 districts of Bangladesh. Based on the history of onset of diarrhea, 133 and 79 patients were distributed in early hospitalization (EH) and delayed hospitalization (DH) group, respectively.
Results: To treat uncontrolled diarrhea at home, antibiotic therapy was initiated in 36.7% (n = 79) of patients in delayed hospitalization (DH) group without any valid prescription whereas only 7.5% (n = 133) of patients in early hospitalization (EH) group received antibiotics (P<0.05). In DH group, 67.1% (n = 79) of children found different antibiotic therapies for the treatment of their diarrhea with or without other hospital acquired infections during their extended hospital-stay period resulted in antibiotic-associated adverse events (AAAEs) in 17.7% of patients whereas 21.1% (n = 133) of patients in EH group received antibiotics caused AAAEs in 2.2% of patients (P=0.001). The children of EH group who received doctors’ consultations and hospitalized within two days of the onset of diarrhea stayed in hospital for a maximum of 4 days which was more than two-times lower than that of the children in DH group (P<0.05) (stayed for a maximum of 10 days) visited doctors and admitted to hospitals at a later stage of diarrheal-onset.
Conclusions: Early doctor visit and hospitalization of under-two children with uncontrolled moderate-diarrhea may reduce the severity of the disease, risk of severe acute malnutrition, minimize the use of antibiotics with minimum chance of occurrence of adverse drug events and cause early discharge from hospital.
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Type of Study: Original Article | Subject: Pediatric Infectious Diseases
Received: 2020/07/8 | Accepted: 2020/11/8

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