Targeting Copper Dyshomeostasis as a Pathophysiological Basis of Childhood Obesity - the Latest Facts

Jaksic, Marina; Martinovic, Milica; Nedovic Vukovic, Mirjana

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Targeting Copper Dyshomeostasis as a Pathophysiological Basis of Childhood Obesity - the Latest Facts

Marina Jaksic

¹, Milica Martinovic²

, Mirjana Nedovic Vukovic³

1- Department of Laboratory Diagnostics, Institute for Children's Diseases, Clinical Center of Montenegro, Podgorica, Montenegro. , marinaj@ucg.ac.me
2- Department of Pathological Physiology, Medical Faculty, University of Montenegro, Podgorica, Montenegro.
3- Center for Health System Evidence and Research in Public Health, Department of Health Statistics, Institute for Public Health of Montenegro, Podgorica, Montenegro.

Abstract: (378 Views)

Context: Childhood pre-obesity and obesity rates have been rapidly growing worldwide over the past decades. Copper homeostasis is gaining increasing attention in the physiopathology of obesity. Strong evidences indicate that a disturbance of copper homeostasis plays an important role in the development of obesity and its related comorbidities. Under physiological conditions, copper plays a significant role in regulatory, immunologic, and antioxidant functions resulting in protection against inflammation and oxidative stress, and consequently against the known comorbidities of obesity. Nevertheless, despite the growing body of research, information about copper status in obesity, particularly in childhood obesity, is scarce.
Evidence Acquisition: The aim of this brief narrative review is to examine the latest data published in the last five years using databases such as PubMed, Scopus, Unpaywall (COBISS), and EBSCO to emphasize the major current findings in research related to this topic.
Results and Conclusions: The most recent studies have yielded strong evidence in support of altered copper status in childhood obesity, nevertheless, further studies are needed to clarify the role of copper in the physiopathology of childhood obesity.

Keywords: Childhood obesity, Childhood overweight, Serum copper, Copper homeostasis

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Type of Study: Narrative Review | Subject: Pediatric Endocrinology
Received: 2023/12/5 | Accepted: 2019/07/19

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