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Volume 12, Issue 2 (4-2024)
J. Pediatr. Rev 2024, 12(2): 153-170 |
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Yousefifard M, Ahmadzadeh K, Madani Neishaboori A, Rafiei Alavi S N, Rafiei Alavi S R, Ahmadzadeh H, et al . A Systematic Review on the Risk Factors of Steroid-Sensitive Nephrotic Syndrome Relapse in the Pediatric Population. J. Pediatr. Rev 2024; 12 (2) :153-170
URL: http://jpr.mazums.ac.ir/article-1-622-en.html
URL: http://jpr.mazums.ac.ir/article-1-622-en.html
Mahmoud Yousefifard1 
, Koohyar Ahmadzadeh1 , Arian Madani Neishaboori1 , Seyedeh Niloufar Rafiei Alavi1 , Seyedeh Romina Rafiei Alavi2 , Hooman Ahmadzadeh3 , Amirmohammad Toloui1 , Mohammed I M Gubari4 , Michael E. Jones5 , Nematollah Ataei6 , Mojtaba Fazel6 , Mostafa Hosseini *7
, Koohyar Ahmadzadeh1 , Arian Madani Neishaboori1 , Seyedeh Niloufar Rafiei Alavi1 , Seyedeh Romina Rafiei Alavi2 , Hooman Ahmadzadeh3 , Amirmohammad Toloui1 , Mohammed I M Gubari4 , Michael E. Jones5 , Nematollah Ataei6 , Mojtaba Fazel6 , Mostafa Hosseini *7
1- Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
2- Department of Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3- Department of Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
4- Department of Community Medicine, College of Medicine, University of Sulaimani, Sulaimani, Iraq.
5- Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
6- Pediatrics Chronic Kidney Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran.
7- Pediatrics Chronic Kidney Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran. ,mhossein110@yahoo.com
2- Department of Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3- Department of Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
4- Department of Community Medicine, College of Medicine, University of Sulaimani, Sulaimani, Iraq.
5- Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
6- Pediatrics Chronic Kidney Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran.
7- Pediatrics Chronic Kidney Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran. ,
Abstract: (1401 Views)
Background: Identifying affecting and predictive factors of steroid-sensitive nephrotic syndrome’s (SSNS's) outcome may greatly benefit the proper management of SSNS patients.
Objectives: The current systematic review comprehensively reviews all available evidence on the risk factors of SSNS relapse in children and adolescents.
Methods: An extensive search was conducted on the electronic databases of Medline, Embase, Web of Science, and Scopus until February 18, 2024. Studies investigating the risk factors of relapse were included in this systematic review.
Results: A total of 11 articles were included. Age, gender, and laboratory variables, such as serum creatinine and serum protein are not risk factors for relapse in these studies. Possible associations were reported for risk factors, such as the number of relapses and response time. Overall, the studies reported conflicting results on the value of relapse risk factors.
Conclusions: Although factors, such as hematuria, hypertension, time from treatment to response, and number of relapses have been proposed as possible risk factors for relapse, no conclusion can be reached due to the heterogeneity of studies. Future studies should have more conforming designs to make comparisons more reliable.
Objectives: The current systematic review comprehensively reviews all available evidence on the risk factors of SSNS relapse in children and adolescents.
Methods: An extensive search was conducted on the electronic databases of Medline, Embase, Web of Science, and Scopus until February 18, 2024. Studies investigating the risk factors of relapse were included in this systematic review.
Results: A total of 11 articles were included. Age, gender, and laboratory variables, such as serum creatinine and serum protein are not risk factors for relapse in these studies. Possible associations were reported for risk factors, such as the number of relapses and response time. Overall, the studies reported conflicting results on the value of relapse risk factors.
Conclusions: Although factors, such as hematuria, hypertension, time from treatment to response, and number of relapses have been proposed as possible risk factors for relapse, no conclusion can be reached due to the heterogeneity of studies. Future studies should have more conforming designs to make comparisons more reliable.
Type of Study: Systematic Review |
Subject:
Pediatric Nephrology
Received: 2024/01/17 | Accepted: 2024/03/16 | Published: 2024/04/1
Received: 2024/01/17 | Accepted: 2024/03/16 | Published: 2024/04/1
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