Volume 13, Issue 2 (4-2025)                   J. Pediatr. Rev 2025, 13(2): 133-138 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ghorbani-khosroshahi N, Azad G, Nili F, Mohkam M, Gholamali-Majdabadi H. Atypical Presentation of Thin Basement Membrane Disease in a Child: Diagnostic and Management Considerations. J. Pediatr. Rev 2025; 13 (2) :133-138
URL: http://jpr.mazums.ac.ir/article-1-729-en.html
1- Pediatric Nephrology Research Center, Research Institute for Children’s Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2- School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , ghazalazad79@gmail.com
3- Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
Abstract:   (86 Views)
Background: Thin basement membrane disease (TBMD) is a common cause of persistent hematuria and can be challenging to distinguish from other glomerular disorders due to overlapping clinical features. This case report highlights the diagnostic challenges associated with TBMD. 
Case Presentation: A 4-year-old boy was admitted for evaluation of abdominal pain and tea-colored urine following an appendectomy. Initial urinalysis revealed significant hematuria (red blood cell (RBC) count: 50-60/HPF). Additional findings, including proteinuria and maculopapular rashes, raised suspicion of Henoch-Schoenlein Purpura as a differential diagnosis. Despite treatment with corticosteroids and enalapril, recurrent hematuria persisted, particularly following upper respiratory infections. A renal biopsy demonstrated thinning of the glomerular basement membrane (GBM) (170 mm), which is a finding consistent with TBMD. 
Conclusions: We report a pediatric patient diagnosed with TBMD based on renal biopsy, who presented with recurrent hematuria. The diagnostic challenge in this case was due to the atypical extrarenal manifestations of TBMD, which initially suggested Henoch-Schonlein Purpura. However, as symptoms evolved, suspicion of Henoch-Schoenlein Purpura diminished. Ultimately, a biopsy was essential in establishing the final diagnosis. This case highlights the importance of considering TBMD in the differential diagnosis of glomerular hematuria, even when atypical features suggest alternative diagnoses. 
Full-Text [PDF 1932 kb]   (43 Downloads)    
Type of Study: Case & Review | Subject: Pediatric Nephrology
Received: 2025/01/23 | Accepted: 2025/03/15 | Published: 2025/04/1

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2025 CC BY-NC 4.0 | Journal of Pediatrics Review

Designed & Developed by : Yektaweb