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Volume 13, Issue 4 (10-2025)
J. Pediatr. Rev 2025, 13(4): 281-288 |
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Talebi Anaraki K, Yazdi M, Moalem S, Heidari-Beni M, Khademian M, Kelishadi R. Association Between Zinc and Pediatric Metabolic Syndrome: A Systematic Review and Meta-analysis. J. Pediatr. Rev 2025; 13 (4) :281-288
URL: http://jpr.mazums.ac.ir/article-1-732-en.html
URL: http://jpr.mazums.ac.ir/article-1-732-en.html
Kasra Talebi Anaraki1 
, Maryam Yazdi1 , Sepideh Moalem2 , Motahar Heidari-Beni *3 , Majid Khademian1 , Roya Kelishadi1
, Maryam Yazdi1 , Sepideh Moalem2 , Motahar Heidari-Beni *3 , Majid Khademian1 , Roya Kelishadi1
1- Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
2- Department of Pediatrics, School of Medicine, Imam Hossein Children’s Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
3- Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran. ,heidari.motahar@gmail.com
2- Department of Pediatrics, School of Medicine, Imam Hossein Children’s Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
3- Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran. ,
Abstract: (15 Views)
Background: The increasing prevalence of metabolic syndrome (MetS) in the pediatric population underscores a critical need for understanding dietary and micronutrient factors, including the role of zinc in metabolic regulation. Despite the well-known importance of zinc in metabolic functions, there are contradictory results regarding its association with pediatric MetS.
Objectives: We aimed to perform a comprehensive review of the studies on the association between serum zinc level and dietary zinc intake with MetS in children and adolescents.
Methods: This is a systematic review and meta-analysis study conducted in accordance with the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. The related studies in English published up to the end of May 2024 were searched in PubMed, Scopus, and Web of Science. The observational studies with high quality (assessed using the Newcastle-Ottawa scale [(NOS)]) were included. Odds ratios (ORs) and 95% confidence intervals (CIs) comparing the risk of MetS in lower levels of zinc versus higher levels were also extracted from each study.
Results: Of 444 initially identified records, four eligible studies were selected for the review. The pooled analysis revealed no significant association between zinc levels (food intake or serum level) and the presence of MetS (P=0.41; OR=1.22, 95% CI, 0.92%, 1.62%). Heterogeneity was not substantial (I2=0.00).
Conclusions: The non-significant association of serum zinc level and dietary zinc intake with MetS in children and adolescents, coupled with substantial heterogeneity across included studies, highlights the complexity of the association between zinc and MetS among youths. This underscores the necessity for further longitudinal studies on the association of low zinc levels and the risk of MetS in children and adolescents.
Objectives: We aimed to perform a comprehensive review of the studies on the association between serum zinc level and dietary zinc intake with MetS in children and adolescents.
Methods: This is a systematic review and meta-analysis study conducted in accordance with the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. The related studies in English published up to the end of May 2024 were searched in PubMed, Scopus, and Web of Science. The observational studies with high quality (assessed using the Newcastle-Ottawa scale [(NOS)]) were included. Odds ratios (ORs) and 95% confidence intervals (CIs) comparing the risk of MetS in lower levels of zinc versus higher levels were also extracted from each study.
Results: Of 444 initially identified records, four eligible studies were selected for the review. The pooled analysis revealed no significant association between zinc levels (food intake or serum level) and the presence of MetS (P=0.41; OR=1.22, 95% CI, 0.92%, 1.62%). Heterogeneity was not substantial (I2=0.00).
Conclusions: The non-significant association of serum zinc level and dietary zinc intake with MetS in children and adolescents, coupled with substantial heterogeneity across included studies, highlights the complexity of the association between zinc and MetS among youths. This underscores the necessity for further longitudinal studies on the association of low zinc levels and the risk of MetS in children and adolescents.
Type of Study: Meta-analysis Review |
Subject:
Pediatrics
Received: 2025/03/2 | Accepted: 2025/10/18 | Published: 2025/10/18
Received: 2025/03/2 | Accepted: 2025/10/18 | Published: 2025/10/18
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