دوره 8، شماره 2 - ( 1-1399 )                   جلد 8 شماره 2 صفحات 8-8 | برگشت به فهرست نسخه ها

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Karami H, Ghaffari J, Moradi S, Vahedi L, Mohammadi-Kharkeshi F. Humeral and Complement systems in children with acute Immune Thrombocytopenia purpura. J. Pediatr. Rev. 2020; 8 (2) :8-8
URL: http://jpr.mazums.ac.ir/article-1-236-fa.html
Humeral and Complement systems in children with acute Immune Thrombocytopenia purpura. Journal of Pediatrics Review. 1399; 8 (2) :8-8

URL: http://jpr.mazums.ac.ir/article-1-236-fa.html


چکیده:   (855 مشاهده)
Background: Immune thrombocytopenia (ITP) is an autoimmune disorder associated with decreased platelet production and accelerated platelet destruction. An impaired immune system may induce and/or be associated with ITP.
Objectives: The aim of this study was to evaluate complement and humeral immune systems in ITP.
Methods: we evaluated 30 children (under 19 years old) with acute and chronic ITP referred to a tertiary hospital compared to 30 healthy volunteers. We evaluated CBC with differentiation, serum immunoglobulins (IgG, IgE, IgM, IgA, IgG1, IgG2, IgG3, IgG4) by nephelometry; ASO titer by agglutination; CH50, C3, C4 by nephelometry; CD19 by flow cytometry, anti-tetanus antibody titer by ELISA along demographic data in a questionnaire
Results: Our findings showed humeral and complement components were normal in both patients and healthy groups but after using independent t-test, mean serum levels of IgM, IgE, IgG1, C3 and tetanus antibody levels were significantly different between the two groups, their levels being higher in the patient group.
Conclusion: Humoral and complementary immunodeficiency in these patients is unlikely. However, more studies with larger sample sizes are needed.
 
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نوع مطالعه: Original Article |
دریافت: 1398/1/18 | پذیرش: 1398/3/19 | انتشار: 1398/10/9

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