دوره 8، شماره 2 - ( 1-1399 )                   جلد 8 شماره 2 صفحات 133-138 | برگشت به فهرست نسخه ها


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Karami H, Ghaffari J, Moradi S, Vahedi L, Mohammadi-Kharkeshi F. Humoral and Complement Systems in Children With Acute Immune Thrombocytopenic Purpura. J. Pediatr. Rev. 2020; 8 (2) :133-138
URL: http://jpr.mazums.ac.ir/article-1-236-fa.html
Humoral and Complement Systems in Children With Acute Immune Thrombocytopenic Purpura. Journal of Pediatrics Review. 1399; 8 (2) :133-138

URL: http://jpr.mazums.ac.ir/article-1-236-fa.html


چکیده:   (1255 مشاهده)
Background: Immune thrombocytopenia (ITP) is an autoimmune disorder associated with decreased platelet production and accelerated platelet destruction. An impaired immune system may induce by or be associated with ITP. 
Objectives: This study aimed to evaluate complement and humoral immune systems in ITP. 
Methods: We evaluated 30 children (under 19 years old) with acute and chronic ITP referred to a tertiary hospital and compared them with 30 healthy volunteers. We assessed the samples’ CBC with differentiation, serum immunoglobulins (IgG, IgE, IgM, IgA, IgG1, IgG2, IgG3, IgG4) by nephelometry, antistreptolysin O titer by agglutination, CH50, C3, C4 by nephelometry, CD19 by flow cytometry, and anti-tetanus antibody titer by ELISA. Their demographic data were obtained with a questionnaire.
Results: Our findings showed that humoral and complement components were normal in both patients and healthy groups. However, based on independent t test results, the mean serum levels of IgM, IgE, IgG1, C3, and tetanus antibody levels were significantly higher in the patient group.
Conclusions: Humoral and complementary immunodeficiency in these patients is unlikely. However, more studies with larger sample sizes are needed.
متن کامل [PDF 698 kb]   (433 دریافت)    
نوع مطالعه: Original Article |
دریافت: 1398/1/18 | پذیرش: 1398/3/19 | انتشار: 1399/1/13

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