Volume 4, Issue 1 (1-2016)                   J. Pediatr. Rev 2016, 4(1): 0-0 | Back to browse issues page

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Ahmadzadeh-Amiri A, Ahmadzadeh-Amiri A. Epigenetic Diabetic Vascular Complications . J. Pediatr. Rev 2016; 4 (1)
URL: http://jpr.mazums.ac.ir/article-1-114-en.html
1- Student Research Committee, Tehran University of Medical Sciences, Tehran, IR Iran
2- Diabetes Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, IR Iran , ahmadzdh@yahoo.com
Abstract:   (3408 Views)
Diabetic vascular complications (DVC) influence several vital organ systems including cardiovascular, renal, ocular and nervous systems making it a major public health problem. Although extensive researches were performed in this field, the exact mechanisms responsible for these organ damages in diabetes remain obscure. Several metabolic disturbances have been involved in its complication and change in genes associated with these pathways occurred. Gene expression to produce a biologically active protein can be controlled by transcriptional and translational alteration on the head of genes without change in nucleotide composition. These epigenetic adjustments are steady, but possibly reversible and can be transmitted to future generation. Gene expression can be regulated by three epigenetic mechanisms including DNA methylation, histone modifications and noncoding microRNAs (miRNAs) activity. Epigenetic studies must be directed to better realize the role of epigenetic changes to the etiology of DVC and knowledge of epigenetic would play a pivotal role in the application of individualized medicine. Application and development of high technology sequencing combined with more sensitive and advanced methodologies for epigenome studying help to determine specific epigenetic events that stimulate gene responses in patients with diabetes mellitus.
Full-Text [PDF 114 kb]   (1811 Downloads)    
Type of Study: Narrative Review |
Received: 2015/07/4 | Accepted: 2015/10/14 | Published: 2016/01/26

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