Volume 9, Issue 2 (in Press 2021)                   J. Pediatr. Rev 2021, 9(2): 11-11 | Back to browse issues page

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Heidari-Beni M, Riahi R, Mohebpour F, Khademian M, Kelishadi R. A Population-Based Study on the Association of Serum Uric Acid And Cardio-Metabolic Risk Factors in Iranian Children and Adolescents. J. Pediatr. Rev. 2021; 9 (2) :11-11
URL: http://jpr.mazums.ac.ir/article-1-376-en.html
1- Department of Nutrition, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
2- Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
3- Pediatrics Department, Faculty of Medicine, Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
4- Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran. , roya.kelishadi@gmail.com
Abstract:   (337 Views)
Background: Recently, there has been an increasing interest in epidemiological and clinical studies for finding a role of uric acid in cardio-metabolic diseases, especially in children and adolescents. However, these potential relationships still remain unproven and its pathophysiological mechanisms have not been recognized.
Objectives: This study aimed to assess the potential association between serum uric acid (SUA) levels and cardio-metabolic risk factors in a population-based sample of Iranian children and adolescents.
Methods: Data of 595 individuals aged 7–18 years were assessed. Anthropometric measurements and laboratory tests were performed according to standardized protocols.
Results: The mean (SD) age of 595 students was 12.39 ± 3.07 years. The overall mean (SD) of uric acid level among Iranian children and adolescents was 4.22 (1.13) mg/dl, with significant differences between girl and boy participants (4.04 ± 0.97 mg/dl vs 4.38 ± 1.24 mg/dl, respectively, p < 0.05). The prevalence of hyperuricemia based on 90th percentile of SUA levels was 10.6%.  There was positive association between SUA level and abdominal obesity (waist circumference ≥ 90th percentile) (OR: 1.54 – 95% CI: 1.26 to 1.86) and general obesity (sex-specific BMI for >95th percentile) (OR: 2.32 – 95% CI: 1.74 to 3.11).
Conclusions: This study suggests that body mass index and waist circumference are cardio-metabolic risk factors that are significantly associated with serum uric acid levels in children and adolescents.
Type of Study: Original Article | Subject: Pediatric Endocrinology
Received: 2020/12/5 | Accepted: 2021/02/28 | Published: 2021/04/21

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