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1- Non-Communicable Pediatric Disease Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R.Iran. , mehrabanisanaz@gmail.com
2- Non-Communicable Pediatric Disease Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R.Iran.
3- Department of Health Reproductive Research Center, Sari Branch, Islamic Azad University, Sari, Iran
Abstract:   (107 Views)
Background: According to our best knowledge, there are limited studies on gastrointestinal (GI) symptoms and hepatopancreatic involvement in children with coronavirus disease 2019 (COVID- 19) infection  
Objective:  The aim of this review study was to evaluate the GI Symptoms and Abnormal Liver and pancreas function in children with COVID-19 infection.
Methods:  In this review study, various databases including Scopus, PubMed, Google scholar and Web of Science were searched using relevant keywords (COVID-19, Children, Gastrointestinal, Liver, and Pancreas). Descriptive and cross-sectional studies were reviewed in the current study with the main focuses on GI symptoms and elevated liver enzymes in children with COVID-19 infection.
Results: Overall, 27 studies from different countries including Iran, Spain, Turkey, Italy and the United States were selected.  Although the prevalence of GI symptoms varied in different studies, a review of these studies showed that most children with COVID-19 infection experienced GI symptoms. In addition to GI symptoms, there is the possibility of elevated liver enzymes such as alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase or creatine phosphokinase in children with COVID-19 infection.
Conclusion: The COVID-19 infection may present with various GI, hepatic and pancreatic manifestations in children. The difference in prevalence can probably be attributed to the geographical region of the study and the history of the disease.
Full-Text [PDF 1192 kb]   (136 Downloads)    
Type of Study: Review Article | Subject: Pediatrics
Received: 2021/01/19 | Accepted: 2021/05/18

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