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1- Student of Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- MD, Clinical Research Development Unit, Qods Hospital, Qazvin University of Medical Sciences, Qazvin, Iran
3- Associate Professor of Pediatric Endocrinology, Children Growth Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran Tel: + 98 9123212858 , drfa_saffari@yahoo.com
Abstract:   (362 Views)
Background: Puberty is an important milestone in a person's reproductive life. Studies show that the prevalence of precocious puberty is more common in girls than in boys.  
This case study was performed from March 2006 to June 2018 on patients who referred to the endocrine clinic of Qazvin University of Medical Sciences for early puberty.
Methods: This case-series study was performed from March 2006 to June 2018 on patients who referred to the endocrine clinic of Qazvin University of Medical Sciences for precocious puberty. To diagnose premature puberty and find its causes were surveyed sex steroids levels (LH, FSH), thyroid function, and if necessary was performed GnRH test. Height and weight were measured and BMI was calculated. Uterine ultrasound was performed for all of the girls additionally, brain MRI was performed for all boys and girls under age 6 years with precocious puberty. X ray of left hand was performed to assess skeletal growth acceleration.
Based on the type of puberty, patients were divided into three groups: Central precocious puberty (CPP), Peripheral precocious puberty (PP) and normal variant of puberty. Data were collected from the electronic files of patients and analyzed using SPSS 23.
Results: Out of 724 cases, 642 (88.70%) were girls. The mean age of all children was 7.07 (CI 95%: 6.99-7.15) years. 70.5% cases had CPP, 5% of cases had PPP and 24.5% of them had normal variant of puberty. Cases of IPP, PPP, NCPP and premature pubarche were significantly higher in girls than boys (P<0.001). None of the boys had NCPP. Most girls had normal BMI but boys were more obese. Mean bone age and bone age/ age ratio were higher in girls with NCPP (P<0.001).
Conclusion: In our study, most girls and boys had idiopathic precocious puberty, and none of the boys had brain lesion. About half of the cases were overweight or obese, indicating the role of obesity in increasing bone age and the onset of puberty.
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Type of Study: Original Article | Subject: Endocrinology
Received: 2021/02/24 | Accepted: 2021/05/9

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