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1- Children and Adolescent Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran , ghmiri1357@gmail.com
2- Department of Biochemistry, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran
3- General physician, Zahedan University of Medical Sciences, Zahedan, Iran.
Abstract:   (116 Views)
Background: Thalassemia is one of the most prevalent genetic disorders globally, and infections are one of the major causes of death in these patients. Various studies have attributed the increased susceptibility to bacterial infections in thalassemia patients to changes in their immunological status. This research aimed to maesure serum levels of immunoglobulins (Igs) in thalassemia major (TM) patients and in the control group.
Methods: The study included forty TM patients (20 splenectomized and 20 non-splenectomized) and 20 healthy participants (the control group). Three groups were matched for age and gender. Mean serum levels of immunoglobulins (IgG, IgA and IgM) were measured for all individuals by ELISA.  P-value < 0.05 was considered the significance level.
Results: Increased serum IgG and IgA levels and significantly reduced serum IgM levels were observed in the splenectomized patients compared to the non-splenectomized ones. Comparison of the study groups revealed that serum IgG and IgA levels in the splenectomized patients and the mean serum IgM and IgG levels in the non-splenectomized patients were higher than those of the healthy participants. The mean serum IgM level in the splenectomized patients and the mean serum IgG level in the non-splenectomized patients were lower than those of the control group. 
Conclusions: The results showed that splenectomy could cahnge the immunological status of the thalassemia patients. Nevertheless, the exact mechanism for this change was not clear. Another finding was that the study of the serum levels of immunoglobulins might be useful in determining the severity of infections in TM patients
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Type of Study: Original Article | Subject: Pediatrics
Received: 2021/05/28 | Accepted: 2021/09/7

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