Volume 9, Issue 4 (In Press 2021)                   J. Pediatr. Rev 2021, 9(4): 1-1 | Back to browse issues page

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Nasri P, Hosseini-Kordkhyli S E, Jafari-Koulaee A, Hovsepian S, Saneian H, Khademian M et al . Simultaneous Presentation of Autoimmune Hepatitis and Wilson's Disease: A Systematic Review Study. J. Pediatr. Rev. 2021; 9 (4) :1-1
URL: http://jpr.mazums.ac.ir/article-1-414-en.html
1- Metabolic Liver Disease Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
2- Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
3- Ghaem Shahr Razi Hospital, Mazandaran University of Medical Sciences, Sari, Iran.
4- Metabolic Liver Disease Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. , fat.famoori@gmail.com
Abstract:   (452 Views)
Background: Identifying the features of these two diseases in patients with simultaneity of Wilson's disease and autoimmune hepatitis is necessary for the relevant specialists to adopt appropriate treatment.
Objectives: This study was conducted aimed to determine features of a patient, disease, diagnostic studies and therapeutic measures in cases of simultaneity of Wilson's disease and autoimmune hepatitis.
Methods: In order to find evidence related to the objective of this study, databases such as Barakat knowledge network system, SID, and Magiran, Google scholar, Web of Science, ProQuest, Springer, ScienceDirect, Medline via PubMed, and Scopus with specified Persian and English keywords including Wilson's Disease, Autoimmune, and Hepatitis were searched. Inclusion criteria in the present review study included: 1) the study was observational, 2) the study was published in Persian or English. Exclusion criteria included low quality studies based on the score obtained from the checklist. The obtained studies were screened in terms of titles, abstracts and full text, and, after evaluating the quality, the qualified studies entered the review process. In order to extract information, a checklist was designed and data were extracted.
Results: Finally, 10 studies were included in the review process. Totally, information about 14 patients were reported. The Mean (SD) of the participants in the studies was 19 (11) years. Diagnosis direction was autoimmune hepatitis to Wilson's disease in 8 cases, and it was reversed in 3 cases. Simultaneity of autoimmune hepatitis and Wilson's disease was considered in 3 patients with no primary and secondary diagnosis.
Conclusion: Given that simultaneity of Wilson's disease and autoimmune hepatitis is uncommon but important, in the presence of symptoms in these patients, simultaneity of these two diseases should be considered and additional assessments such as serum ceruloplasmin, urinary copper 24 Hourly, molecular genetic testing, MRI, serological tests, ANA, ASMA, AMA, complement level, gammaglobulin, IgG, albumin, Kayser-Fleischer ring eye examination and liver biopsy should be considered for correct diagnosis. If appropriate treatment was started for the disease with a diagnosis of Wilson disease or autoimmune hepatitis, but the response to treatment was not sufficient, it is better to consider the simultaneous occurrence of two diseases or the initial misdiagnosis.
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Type of Study: Systematic Review | Subject: Gastroenterology
Received: 2021/06/20 | Accepted: 2021/08/10 | Published: 2021/10/23

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