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1- Department of Pediatrics, All India Institute of Medical Sciences, Gorakhpur, India.
2- Department of Pediatrics, Maulana Azad Medical College, New Delhi, India.
3- Department of Pediatrics, Maulana Azad Medical College, New Delhi, India. , pallavi86.delhi@gmail.com
Abstract:   (215 Views)
Background: Multisystem Inflammatory Syndrome in Children (MIS-C) associated with coronavirus disease (COVID-19) is a novel syndrome having phenotypic similarity to Kawasaki Disease (KD).
Objective: This study aimed to systematically review demographic profile, clinical spectrum, treatment options and outcome of children and young adults under 21 years of age suffering from MIS-C.
Methods: PubMed and Embase databases were searched from inception to 3rd July 2020.  A total of 39 studies involving 799 participants were included for the review. Study appraisal and synthesis method: Critical appraisal of included studies was done using Joanna Briggs Institute Critical Appraisal Checklist for studies reporting prevalence data. Narrative synthesis was performed through descriptive summaries of demographic variables, clinical features, investigations performed, treatment details and clinical outcomes.
Results: The main presenting complaints were fever (96.4%) followed by gastrointestinal symptoms. Serological evidence of preceding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was documented in 79.1% participants. Ventricular dysfunction (50.2%) was the most common echocardiographic finding. Intensive care was required for 77% of included participants, with 27.2% being mechanically ventilated. 78.1% participants received Intravenous immunoglobulins (IVIG). Overall mortality was estimated to be 1.5%.
Conclusion: (MIS-C) associated with COVID-19 is a clinical mimic of hyperinflammatory states. Larger studies will help in better defining this entity and delineating phenotypic subtypes.
Full-Text [PDF 2570 kb]   (116 Downloads)    
Type of Study: Systematic Review | Subject: Pediatric Infectious Diseases
Received: 2021/09/2 | Accepted: 2021/11/27

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