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1- Metabolic liver Disease Research Center, Isfahan Endocrine and Metabolism Research Center, Department of Pediatric Endocrinology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
2- Department of Pediatric Endocrinology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
3- Metabolic liver Disease Research Center, Department of Pediatric Endocrinology, School of Medicine, Imam Hossien Children’s Hospital, Isfahan University of Medical Sciences, Isfahan, Iran. , silvahovsepsecret@gmail.com
4- Isfahan Endocrine and Metabolism Research Center, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Department of Pediatric Endocrinology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
5- Metabolic liver Disease Research Center, Department of Pediatric Endocrinology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Abstract:   (459 Views)
Background: Lipodystrophy is the most common complication of insulin injection that has not been studied yet in children with type 1 diabetes mellitus (T1DM) in Isfahan.
Objectives: This study aimed to evaluate the prevalence of insulin injection-induced lipodystrophy based on related risk factors in children and adolescents withT1DM.
Methods: In this cross-sectional study children and adolescents aged less than 18 years old with T1DM who referred to the endocrinology clinic of Imam Hossein Hospital in Isfahan in 2019 were enrolled. The baseline, anthropometric and T1DM related characteristics of the patients were recorded .Lipodystrophy was diagnosed by clinical examination. The characteristics of patients with and without lipodystrophy were compared. The association between Lipodystrophy and disease related factors was investigated.
Results: In this study 194 patients with T1DM (88 boys and 106 girls) aged 3 to 18 years old were evaluated. Lipodystrophy was diagnosed in 91 patients (46.9%), of which 64 patients (33%) had grade 1, 24 patients (12.4%) had grade 2 and 3 patients (1.5%) had grade 3 lipodystrophy. There was a significant difference in the frequency of lipodystrophy based on age, BMI, patient education, parent education, insulin injection site, duration of diabetes, injection site change, needle change, insulin dose, HbA1c, and hypoglycemia (p <0.05). Regression analysis indicated that there is a significant association between presence of lipodystrophy and HbA1c (p<0.001, t=7.20), Insulin dose (p<0.001, t=4.47), BMI (p<0.001, t= -3.78) and duration of T1DM (p=0.002, t=3.15).
Conclusions: In this study we reported a high prevalence of lipodystrophy among T1DM patients in Isfahan. From studied risk factors duration of diabetes, lower BMI, using high dose of insulin and uncontrolled diabetes (HbA1c>7) were the most important risk factors for lipodystrophy.
 
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Type of Study: Original Article | Subject: Pediatric Endocrinology
Received: 2021/10/26 | Accepted: 2021/11/27

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