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1- Dentistry Student, Student Research Committee, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran
2- Department of Pediatric Dentistry, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran , Azamnahvi.pedodontist@gmail.com
Abstract:   (90 Views)
Context: Early childhood caries (ECC) have many etiologies such as families' socioeconomic status, parents' education and awareness, prolonged and improper bottle or breastfeeding, consuming sweet foods and high-sugar diets, brushing techniques, immaturity of children's immune system, family size, and Streptococcus mutans.
Evidence Acquisition: The data we used in our review were searched from articles published between 1950 to 2021 and using early childhood caries (ECC), children, saliva, salivary biomarkers, salivary enzymes, salivary peptides, salivary proteins and immunity as keywords, collected from official web pages (Scopus, PubMed, Embase and Google scholar) and documents published from different international institutions. The search was limited to articles published in English language. After abstract screening, full-text of 194 related studies were reviewed. Finally, 78 most related studies were selected.
Resultsand Conclusions: ECC-related salivary proteins and peptides are Proline-rich proteins, salivary mucins, Lactoferrin, Immunoglobulins, Toll-like receptors(TLRs), Lysozyme, Histatins, Statherin, Defensins, Calprotectin, and Cytokines. ECC-related enzymes are Amylase, Lysozyme, Lactoperoxidase, Alkaline phosphatase, Carbonic anhydrase VI, Lactate dehydrogenase, and Glucosyltransferase B. Immunity factors affecting ECC include IgA(sIgA), IgG, IgM, Salivary mucins, Lactoferrin, TLRs, Histatins, Statins, Defensins, Calprotectin, Lysozyme, Lactoperoxidase, Cytokines and interleukins, Cathelicidin (LL-37), Agglutinin, Cysteine, and Neutrophils.
Full-Text [PDF 915 kb]   (48 Downloads)    
Type of Study: Narrative Review | Subject: Dentistry
Received: 2022/03/2 | Accepted: 2022/10/15

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