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Abstract:   (83 Views)
Germ cell tumors (GCTs) are a heterogenous group of neoplasms that arise from the primordial germ cells of the human embryo, which are normally destined to produce reproductive cells sperm or ova. 
GCTs can be present in both gonadal (GGCTs) and extragonadal (EGGCTs) sites. Pediatric GCTs are relatively rare tumors with incidence of 2-3%. Primary mediastinal germ cell tumors (PMGCTs) are a very rare EGGCTs that arise in the anterior mediastinum.
In this report we present the case of a 16-year-old boy with primary seminoma arising in the anterior mediastinum. The patient presented with the symptoms of cough, fever and chest tightness. CT finding was in favour of a large expansive process measuring 12.4x6.7x14.2 cm in the anterior mediastinum, accompanied by conglomeration of hilar lymph nodes in the level of brachiocephalic veins juncture. Fine needle biopsy and core biopsy were performed transthoracically, under control of MSCT. Based upon histology and immunohistochemistry
 the diagnosis of mediastinal germ cell tumor with imunophenotype of seminoma was made.
The patient was treated with 4 cycles of chemotherapy by BEP protocol without significant side effects and toxicities. The patient remained disease- free for 16 months.
The purpose of reporting this case is to confirm that chemotherapy with cisplatin based regimens has markedly improved the outcome of adults and children with GCTs as well.
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Type of Study: Case Report and Review of Literature | Subject: Pediatric Hematology and Oncology
Received: 2022/04/14 | Accepted: 2022/08/29

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